His laboratory was the first to describe vascular endothelial function in the state of health and endothelial dysfunction in atherosclerosis in humans (N Engl J Med 1986; 315:1046-1051). He identified risk factors associated with endothelial dysfunction (Circulation 1990; 81:491-497) and showed that endothelial dysfunction can be corrected with statin therapy (N Engl J Med 1995; 332:488-493). Currently, Dr. Ganz is making important discoveries in another field - precision medicine enabled by proteomics and machine learning. He is using modified aptamers as binding reagents to quantify the levels of thousands of proteins simultaneously in blood in order to elucidate the risk and biological basis of diseases (JAMA 2016;315:2532-2541; Circulation 2018;137:999-1010; Nature Medicine 2019;25:1851-1857). Dr. Ganz has authored over 250 peer-reviewed articles, many widely cited and published in the top tier medical journals.