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Bio
Research interests
My research is focused on advanced breast cancer with particular emphasis on bone metastasis. Primarily, this involves using a complement of in vitro and in vivo model systems to investigate the molecular alterations that are acquired by breast cancer cells causing them to metastases to bone.
I hypothesise that metastases are a result of a stepwise accumulation of genetic mutations and that distinct molecular alterations are required at the different stages in the metastatic process; molecules involved in intravasation are not those involved in tissue homing and colonisation.
The aims of my research are to identify specific molecular determinants involved in tumour cell intravasation, homing to bone and colonisation of the metastatic site and to use this information to develop and apply new therapies for the treatment of breast cancer bone metastasis.
Research Interests
Papers共 138 篇Author StatisticsCo-AuthorSimilar Experts
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Mai Morita, Fawaz Arshad, Lewis A. Quayle, Christopher N. George,Diane V. Lefley,Ivo Kalajzic, Meena Balsubramanian,Tugba Cebe, Gwen Reilly, Nicolas J. Bishop,Penelope D. Ottewell
Bone Reportspp.101795, (2024)
Journal of Bone Oncology (2024): 100608-100608
crossref(2023)
Amy Kwan,Natalie Winder, Emer Atkinson,Haider Al-Janabi,Richard J. Allen,Russell Hughes, Mohammed Moamin, Rikah Louie, Dhanajay Evans, Matthew Hutchinson, Drew Capper,Katie Cox,
crossref(2023)
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Author Statistics
#Papers: 135
#Citation: 3180
H-Index: 33
G-Index: 55
Sociability: 6
Diversity: 0
Activity: 1
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