Research description
Our team is aiming to understand human immune system variation in health and disease, and understand the factors that shape human immune systems. We are also interested in defining better metrics of immune system health and develop methods for better immune system analyses in human patients.

As a physician at the department of pediatrics at the Karolinska University Hospital, I have a particular interest in understanding when and how human immune systems are shaped early in life, and the influences by environmental exposures such as the microbiome, infections, vaccines, nutritional components etc in this process.

We are firmly convinced that the way to understand human immune systems and their variation, it is essential that all system components are analyzed simultaneously and relationships between these taken into account. This have recently been made possible with the development of novel high-dimensional methods operating at single-cell resolution, such as Mass cytometry, mRNA-sequencing and integrative multiomics analyses.

To analyze human immune systems at the systems-level, we are developing novel experimental and computational methods.