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职业迁徙
个人简介
My own research interests continue to be in two main areas: the first is to solve detailed protein structures (especially by X-ray crystallography) and, in collaboration with researchers carrying out functional studies, figure out how they work; the second is empirical studies of ultrahigh-resolution protein structures in the protein data bank to discover details and principles of protein structure that have not yet been recognized. Two longer-term projects in the first area have been studies of peroxiredoxins and their roles in redox protection and hydrogen peroxide signaling and studies of a variety of flavoenzymes and thei redox activities. Projects in the data-mining area have included work on (i) the non-planarity of the peptide bond, (ii) how covalent geometry depends on conformation and (iii) conformational preferences of protein chains. A “Protein Geometry Database” we developed is a useful tool for these and other studies. One additional interest has been how protein crystallographers can make the best use of their data. Collaboratively with Kay Diederichs (Konstanz, Germany), we showed that conventional practices commonly led researchers to discard weak but still useful data (see "Assessing and maximizing data quality in macromolecular crystallography" Curr Opin Struct Biol (2015) 34:60-68), and proposed two novel statistics, CC1/2 and CC*, as more robust measures of data quality that can improve data collection and structure refinement practices.
研究兴趣
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Chemical reviews (2024)
ACS Central Scienceno. 4 (2023): 816-835
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Journal of Biological Chemistryno. 3 (2023): 103265-103265
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Alex J. Eddins,Riley M. Bednar,Subhashis Jana, Abigail H. Pung,Lea Mbengi,Kyle Meyer,John J. Perona,Richard B. Cooley,P. Andrew Karplus,Ryan A. Mehl
Bioconjugate chemistryno. 12 (2023): 2243-2254
Cell chemical biologyno. 4 (2023): 343-361
Microbiology spectrumno. 6 (2023)
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ACS CENTRAL SCIENCEno. 4 (2023): 816-835
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Elise M Van Fossen, Sonia Grutzius,Carl E Ruby, Dan V Mourich,Chris Cebra,Shay Bracha,P Andrew Karplus,Richard B Cooley,Ryan A Mehl
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