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个人简介
My group has made significant contributions to the understanding of human leukemias, immune disorders, and epithelial cancers. This includes the discovery of tyrosine kinase activity for the ABL gene and the demonstration of the BCR-ABL oncoproteins in human leukemias. This has had practical impact in leading to the development of kinase targeted therapy as an effective treatment for these leukemias and other cancers. Our work also led to the co-discovery of Bruton’s tyrosine kinase which is required for normal B-lymphocyte development, and when mutated leads to X-linked agammaglobulinemia, a form of immune deficiency. New targeted inhibitors for this kinase are of value in treating several types of lymphoma and leukemia. More recent work has concentrated on defining the stem cells and growth regulatory pathways for epithelial cancers of the prostate and other organ sites to help define new types of therapy for these diseases. We have a special interest in developing new immunotherapy targets for these diseases. We also develop new probes and methods for whole body imaging techniques using Positron Emission Tomography (PET) to monitor cancer growth and cellular immune functions.
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Proceedings of the National Academy of Sciences of the United States of Americano. 14 (2024): e2320442121-e2320442121
Grigor Varuzhanyan,Chia-Chun Chen, Jack Freeland, Tian He,Wendy Tran,Kai Song,Liang Wang,Donghui Cheng,Shili Xu,Gabriella A. Dibernardo,Favour N Esedebe,Evan R. Abt,
biorxiv(2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 47 (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 21 (2023)
crossref(2023)
crossref(2023)
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