基本信息
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Bio
I’m a physical chemist who is interested in understanding the energy landscape of proteins. I started as a chemistry and physics major in college getting my first taste of research in gravitational physics (which involved a summer at Fermilab). I went to grad school in physical chemistry, working with Dewey Holten at Washington University in St. Louis on the electronic structure of strongly coupled porphyrin pi systems. The goal of the research was to understand these systems as models of the special pair in photosynthetic reaction centers. The work involved femtosecond pump probe spectroscopy and theory. After grad school I went to the James Franck Institute at The University of Chicago to work with Don Levy on high resolution laser induced fluorescence spectroscopy in the gas phase using supersonic jets. I later joined Bob Matthews’ group at Penn State to study protein folding. I’ve worked with Bob and Jill Zitzewitz for approximately two decades, embarking on many projects together both at Penn State and at UMass Med School. The move to UMass allowed me to build what is commonly referred to as “the laserlab” with the purchase of the Ti:sapphire system and harmonic generation optics. This led to our work in time-resolved fluorescence, trFRET, FCS and microfluidic microsecond mixing. The laserlab has continued to grow and now houses a custom single-molecule microscope and a 2-photon microscope for long term live cell imaging. My current efforts are focused on my startup which develops microfluidics devices for high-throughput stability and binding measurements of proteins and also new approaches for grid preparation for cryo-EM.
Research Interests
Papers共 95 篇Author StatisticsCo-AuthorSimilar Experts
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semanticscholar(2022)
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Eric J. Schmidt,Salome Funes,Jeanne E. McKeon,Brittany R. Morgan, Sivakumar Boopathy, Lauren C. O'Connor,Osman Bilsel, Francesca Massi,Antoine Jegou, Daryl A. Bosco
Proceedings of the National Academy of Sciences of the United States of Americano. 23 (2021)
Biophysical journalno. 8 (2020): 1992-2000
Proceedings of the National Academy of Sciences of the United States of Americano. 32 (2020): 18915-18917
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Author Statistics
#Papers: 89
#Citation: 3267
H-Index: 29
G-Index: 57
Sociability: 6
Diversity: 0
Activity: 0
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