Dr. Muratoglu has published 147 peer-reviewed articles and holds 118 issued patents. He played a key role in the discovery of highly crosslinked UHMWPE, a more wear-resistant polymeric material for load-bearing applications in total joints. He also pioneered the use of the antioxidant vitamin E to further stabilize the highly crosslinked UHMWPE. Medical implants fabricated using these technologies have been in clinical use since 1998 with over 10 million implantations worldwide, in total hip, knee and shoulder patients. These technologies markedly reduced the revision rate by increasing the wear and oxidation resistances of the implants and virtually eliminated periprosthetic osteolysis, the number one cause of revision in total joints. The use of these implants in total hip and total knee patients resulted in $2B annual savings in US health care spending.

Highly crosslinked polyethylene also enabled the use of large femoral heads, in clinical use since 2000, substantially reducing the dislocation rate in total hip patients, another major mode of failure in these patients.

The anatomically contoured femoral head, among his inventions, has been cleared by FDA in 2019 and is now in clinical use. This invention is expected to reduce soft tissue impingement and reduce anterior hip pain that is associated with the use of large femoral heads in total hip patients.