Omar Abdel Wahab

基本信息

Career Trajectory

Bio

I currently spend the majority of my time in the laboratory investigating the underlying causes of these disorders by studying the genes of patient samples as well as in vitro and in vivo models. As a member of the Human Oncology and Pathogenesis Program, I have helped to identify and characterize several new genetic abnormalities in the diseases mentioned above. In addition to increasing our understanding of the causes of these disorders, these discoveries have promise in helping to discover targeted therapies.

Research Interests

Papers共 661 篇Author StatisticsCo-AuthorSimilar Experts

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Inherited Resilience to Clonal Hematopoiesis by Modifying Stem Cell RNA Regulation

Gaurav Agarwal,Mateusz Antoszewski, Xueqin Xie, Yash Pershad, Uma P Arora, Chi-Lam Poon, Peng Lyu, Andrew J Lee, Chun-Jie Guo, Tianyi Ye, Laila Barakat Norford, Anna-Lena Neehus, Lucrezia Della Volpe,Lara Wahlster, Diyanath Ranasinghe,Tzu-Chieh Ho,Trevor S Barlowe,Arthur Chow,Alexandra Schurer,James Taggart, Benjamin H Durham,Omar Abdel-Wahab,Kathy L McGraw, James M Allan, Ruslan Soldatov,Alexander G Bick,Michael G Kharas,Vijay G Sankaran

bioRxiv the preprint server for biology (2025)

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Reducing Clinical Trial Eligibility Barriers for Patients with MDS: an Icmds Position Statement

Uma Borate, Kelly Pugh, Allyson Waller, Rina Li Welkie, Ying Huang,Jan Philipp Bewersdorf,Maximilian Stahl,Amy E DeZern,Uwe Platzbecker,Mikkael A Sekeres,Andrew H Wei,Rena J Buckstein,Gail J Roboz,Michael R Savona,Sanam Loghavi,Robert P Hasserjian,Pierre Fenaux,David A Sallman,Christopher S Hourigan,Matteo Giovanni Della Porta, Stephen Nimer,Richard F Little,Valeria Santini,Fabio Efficace,Justin Taylor,Guillermo Garcia-Manero,Olatoyosi Odenike,Tae Kon Kim,Stephanie Halene,Rami S Komrokji,Elizabeth A Griffiths,Peter L Greenberg,Mina L Xu, Zhuoer Xie,Rafael Bejar, Guillermo F Sanz,Mrinal M Patnaik, Maria Figueroa,Hetty E Carraway,Omar Abdel-Wahab, Daniel Starczynowski,Eric Padron,Jacqueline Boultwood, Steven Gore, Naval G Daver,Jane E Churpek,Ravindra Majeti,John M Bennett,Alan F List,Andrew M Brunner,Amer M Zeidan

Bloodno. 13 (2025): 1369-1381

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A Microglia Clonal Inflammatory Disorder in Alzheimer’s Disease

Rocio Vicario,Stamatina Fragkogianni, Leslie Weber,Tomi Lazarov,Yang Hu,Samantha Y Hayashi,Barbara Craddock,Nicholas D Socci, Araitz Alberdi, Ann Baako, Oyku Ay,Masato Ogishi,Estibaliz Lopez-Rodrigo,Rajya Kappagantula,Agnes Viale,Christine A Iacobuzio-Donahue,Ting Zhou,Richard M Ransohoff, Richard Chesworth,Netherlands Brain Bank,Omar Abdel-Wahab,Bertrand Boisson,Olivier Elemento,Jean-Laurent Casanova,W Todd Miller,Frédéric Geissmann

eLife (2025)

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Role of Clonal Inflammatory Microglia in Histiocytosis-Associated Neurodegeneration

Rocio Vicario, Stamatina Fragkogianni,Maria Pokrovskii, Carina Meyer, Estibaliz Lopez-Rodrigo,Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay,Isabelle Plu,Véronique Sazdovitch, Sebastien Heritier,Fleur Cohen-Aubart, Natalia Shor,Makoto Miyara,Florence Nguyen-Khac,Agnes Viale,Ahmed Idbaih,Zahir Amoura, Marc K Rosenblum, Haochen Zhang, Elias-Ramzey Karnoub,Palash Sashittal, Akhil Jakatdar, Christine A Iacobuzio-Donahue,Omar Abdel-Wahab, Viviane Tabar, Nicholas D Socci,Olivier Elemento,Eli L Diamond,Bertrand Boisson,Jean-Laurent Casanova,Danielle Seilhean,Julien Haroche,Jean Donadieu,Frederic Geissmann

Neuronno. 7 (2025): 1065-1081.e13

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RBM10 Loss Promotes Metastases by Aberrant Splicing of Cytoskeletal and Extracellular Matrix Mrnas

Gnana P Krishnamoorthy,Anthony R Glover,Brian R Untch, Nickole Sigcha-Coello,Bin Xu, Dina Vukel, Yi Liu,Vera Tiedje,Jose Mario Bello Pineda,Katherine Berman,Prasanna P Tamarapu,Adrian Acuña-Ruiz,Mahesh Saqcena,Elisa de Stanchina,Laura Boucai,Ronald A Ghossein,Jeffrey A Knauf,Omar Abdel-Wahab,Robert K Bradley,James A Fagin

The Journal of experimental medicineno. 5 (2025)

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Phase Ib Study of PRT543, an Oral Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, in Patients with Advanced Splicing Factor-Mutant Myeloid Malignancies

Jan Philipp Bewersdorf,Xiaoli Mi,Bin Lu,Andrew Kuykendall,David Sallman,Manish Patel,Don Stevens,Alexander Philipovskiy,Grerk Sutamtewagul,Lucia Masarova,Gina Keiffer,Amit Verma,Neha Bhagwat,Min Wang, Andrew Moore,Joseph Rager,Diane Heiser,Sunhee Ro, Wan-Jen Hong,Omar Abdel-Wahab,Eytan M. Stein

Leukemiapp.1-5, (2025)

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TP53 Mutations and TET2 Deficiency Cooperate to Drive Leukemogenesis and Establish an Immunosuppressive Environment

Pu Zhang, Ethan C Whipp, Sarah J Skuli,Mehdi Gharghabi,Caner Saygin, Steven A Sher,Martin Carroll, Xiangyu Pan, Eric D Eisenmann, Tzung-Huei Lai,Bonnie K Harrington, Wing Keung Chan, Youssef, Bingyi Chen, Alex Penson, Alexander M Lewis, Cynthia R Castro, Nina Fox, Ali Cihan, Jean-Benoit Le Luduec,Susan DeWolf, Tierney Kauffman,Alice S Mims, Daniel Canfield,Hannah Phillips, Katie E Williams, Jami Shaffer,Arletta Lozanski, Tzyy-Jye Doong,Gerard Lozanski, Charlene Mao,Christopher J Walker,James S Blachly,Anthony F Daniyan,Lapo Alinari,Robert A Baiocchi,Yiping Yang,Nicole R Grieselhuber,Moray J Campbell,Sharyn D Baker,Bradley W Blaser,Omar Abdel-Wahab, Rosa Lapalombella

The Journal of clinical investigationno. 10 (2025)

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Altered Mrna Splicing Mimics Chromosome Loss and Drives Pancreatic Cancer

Natasha Pinto Medici,Diana Martinez-Saucedo, Danny Lee, Tianyi Chu,Robert Tseng,Vincent Cannataro,Jeffrey Townsend,Christine Iacobuzio-Donahue,Marie Robert,Omar Abdel-Wahab,Steven D. Leach,Luisa Escobar-Hoyos

CANCER RESEARCHno. 17 (2024)

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Papers共 661 篇Author StatisticsCo-AuthorSimilar Experts