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Bio
I am a biologist and biochemist interested in bridging fundamental and clinic research and providing mechanistic insights into human disease by elucidation of molecular mechanisms triggered by homocysteine and deficient methylation.
Elevation of homocystein (Hcy) levels in the blood, a common pathological condition termed hyperhomocysteinemia (HHcy), is especially prevalent in the elderly and to 2/3 is due to deficiency of vitamins that are required for Hcy degradation. Elevation of Hcy levels is connected to numerous diseases including cardiovascular diseases. The mechanisms how Hcy triggers associated pathology are elusive and the therapies are completely missing.
We showed that Hcy regulates fatty acid synthesis and S-adenosyl-L-homocysteine (SAH), which is synthesized from Hcy in response to elevation of Hcy levels, mediates this regulation. For this we functionally expressed alternative bacterial pathway for SAH hydrolysis in yeast and showed that SAH degradation by this pathway suppresses deregulation of lipid metabolism in response to Hcy supplementation.
Elevated Hcy is an independent risk factor for atherosclerosis and is strongly linked to cardiovascular mortality. We showed that diet deficient in vitamins required for Hcy degradation leads to atherosclerotic transformation of the aorta already in the absence of hypercholesterolemia and aggravates atherosclerosis development in its presence in a balloon-injured rabbit model of atherosclerosis.
Keywords: homocysteine, S-adenosyl- L-homocysteine, methylation, methylation deficiency, lipid metabolism, atherosclerosis, cardiovascular diseases, yeast, rabbits
Research Interests
Papers共 15 篇Author StatisticsCo-AuthorSimilar Experts
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2024): 117244-117244
Research Square (Research Square) (2022)
Research Square (Research Square) (2022)
G. Almer, M. Brunner, A. Schwarz,C. Diwoky,M. Lechleitner,G. Sommer,D. Kolb,H. Wolinski, W. K. Oswald,P. Opriessnig,G. Horl,A. Groselj-Strele,
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#Papers: 15
#Citation: 840
H-Index: 10
G-Index: 10
Sociability: 5
Diversity: 2
Activity: 1
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