基本信息
浏览量:57
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
In 2002, the mechanisms of immune escape from tumors were still not elucidated, leading to the paradox of the coexistence of T-cell-mediated anti-tumor immunity and unexplained metastatic development in T-cell areas of lymphoid organs. We have notably demonstrated that tumor-infiltrating dendritic cells are naturally loaded with tumor-associated antigens (Preynat-Seauve et al., 2006) and capable of protecting against tumor development. In an effort to understand the paradox of metastatic development in T-cell areas of lymphoid tissues, our main achievement in this field was to understand for the first time that tumor-associated antigens were tolerated by antigen-presenting cells in draining lymph nodes distant from the tumor site, thus allowing metastatic development in lymphoid tissues (Preynat-Seauve et al., 2007).
The increasing emergence of cell therapy applications from embryonic Pluripotent Stem Cells (ePSCs) in 2006 allowed us to work on several tissue engineering applications. We described the first possibility to create a 3D self-organized neural tissue from ePSCs (Preynat-Seauve, Suter, et al., 2009), thus opening the way to the important concept of human neural tissue engineering. We also developed the possibility of modelling glioblastoma in ePSC-derived neural tissue (Nayernia et al., 2013). Regarding the cell therapy potential of ePSC-derived cells, we have also demonstrated the immunogenicity of ePSC-derived neural grafts under allogeneic conditions (Preynat-Seauve, de Rham, et al., 2009)
More recently, we have conducted research on the impact of environmental regulations of Adipose-derived Stromal Cells (ASCs). We demonstrated that ASC spheroids improved fat graft uptake for reconstructive surgery applications compared to ASC suspensions (El Harane et al., 2022). To maintain the benefits of ASC clustering while adding pro-angiogenic regulations, we investigated gelatin-based scaffolds, reasoning that the RGD of gelatin might enhance the angiogenic capabilities of ASCs. We found that gelatin promoted a strong angiogenic response on wounds (N.C. Brembilla et al., 2023). The combination of ASCs with gelatin-based scaffolds has also been patented (Cellular substitute and methods of preparation thereof, WO2021053132A1) and has been the subject of a preclinical study. This new ASC regulation has the potential to develop a new stage of ASC regulation, promising for the treatment of chronic wounds, as discussed in our recently published invited review on this topic (N. C. Brembilla et al., 2023). A spin off from the University of Geneva, Heketiss SA, has been established to ensure the pharmaceutical development of angiogenic ASCs.
研究兴趣
论文共 76 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2023)
crossref(2023)
Prisca Schuler,Emmanuel Contassot,Magali Irla,Stéphanie Hugues,Olivier Preynat-Seauve, Friederich Beermann, Alena Donda, L.E. French,Bertrand Huard
crossref(2023)
Cellsno. 1001 (2023): 1001-1001
Olivier Preynat-Seauve,Emmanuel Contassot, Prisca Schuler,Vincent Piguet, Lars E. French,Bertrand Huard
crossref(2023)
Olivier Preynat-Seauve,Emmanuel Contassot, Prisca Schuler,Vincent Piguet, Lars E. French,Bertrand Huard
crossref(2023)
Arthur Bassot, Helena Dragic,Sarah Al Haddad,Laurine Moindrot,Soline Odouard,Francesca Corlazzoli,Eliana Marinari,Alexandra Bomane, Augustin Brassens,Antoine Marteyn,Youssef Hibaoui,Tom J. Petty,
Cell death & diseaseno. 9 (2023): 630-16
Prisca Schuler,Emmanuel Contassot,Magali Irla,Stéphanie Hugues,Olivier Preynat-Seauve, Friederich Beermann,Alena Donda, L.E. French,Bertrand Huard
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn