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Hemostatic plug formation upon blood vessel breach is initiated by platelet recruitment, activation and aggregation in concert with thrombin generation and fibrin formation. However, a similar process can also lead to pathological processes including deep vein thrombosis, ischemic stroke, or myocardial infarction, among others. We have developed narrow mechanism-specific agents targeting the intrinsic pathway of coagulation and demonstrated that experimental thrombosis and platelet production in primates is interrupted by selective inhibition of activation of coagulation factor (F)XI by FXIIa. Our current studies are focused on defining the role of the endothelium in inactivating FXI, as well as studies on whether inhibiting FXI is beneficial in a non-human primate model of sepsis. We have recently published the first data from our Phase 1 clinical trial on the safety of inhibition of FXI, and are testing the efficacy of FXI inhibition in dialysis in a Phase 2 clinical trial. The understanding of the mechanisms by which the intrinsic pathway of coagulation promotes thrombus formation may support the rationale for the development of selective, safe and effective antithrombotic strategies targeting FXI.
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Papers共 396 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL OF THROMBOSIS AND HAEMOSTASISno. 5 (2024): 1433-1446
Samantha A Moellmer, Olivia L Hagen, Parsa A Farhang, Victoria R Duke, Meghan E Fallon, Monica T Hinds,Owen J T McCarty,Jamie O Lo, Karina H Nakayama
PloS oneno. 7 (2024): e0306868-e0306868
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2024)
Research and Practice in Thrombosis and Haemostasisno. 1 (2024): 102276-102276
bioRxiv : the preprint server for biology (2024)
Jie Hu, William Anderson, Emily Hayes, Ellie Annah Strauss, Jordan Lang, Josh Bacos, Noah Simacek,Helen H Vu,Owen J T McCarty, Hoyeon Kim, Youngbok Abraham Kang
Artificial organs (2024)
JOURNAL OF THROMBOSIS AND HAEMOSTASISno. 1 (2024): 225-237
Journal of Translational Medicineno. 1 (2024): 1-11
Young Bok Abraham Kang, Jie Hu, William S. Anderson, Emily Hayes, Esther Strauss, Jing Yu Lang, James M. Bacos, Noah Simacek, Lorna Gibson,Owen J. T. McCarty
Authorea (Authorea) (2023)
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Author Statistics
#Papers: 395
#Citation: 9209
H-Index: 51
G-Index: 81
Sociability: 7
Diversity: 0
Activity: 5
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