基本信息
浏览量:4
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Prof. Dekker has contributed seminal advances at the top of her field of biological physics. Her research focuses on fundamental biological topics such as transcription, replication, and topology that have also a strong link to biomedical research. In order to understand these critical biological processes, she quantitatively probes the dynamics of single molecules of DNA, enzymes, and molecular motors, thus generating a precise and mechanistic biophysical perspective. Her successful research efforts have included real-time studies of processive molecular motors (e.g. polymerases) on DNA and RNA, experiments that probe the mechanisms of DNA-binding proteins involved in DNA compaction (e.g. nucleosomes, tetrasomes) and the termination of replication, and ground-breaking experiments on the understanding of chemotherapeutic inhibitors in clinical use, thus uncovering a new mechanism through which they influence the activity of topoisomerase enzymes. Her research at the single-molecule level was also extended to the context of live bacterial cells, which places her research group in the unique position of being able to quantitatively compare the behavior of individual biological molecules both in vitro and in vivo.
In recent years, Prof. Dekker has concentrated her research efforts in the study of the dynamics of the complete eukaryotic replication fork at the single-molecule level. This builds on the ability of many biochemists, which culminated in the reconstitution of the eukaryotic replication fork in bulk in 2015. Since then, her group has been able to purify all the proteins involved in yeast replication and studies the loading and activation of the yeast replisome using high-end single-molecule equipment. Understanding the mechanisms that underlie eukaryotic replication provides a key that will link to our understanding of disease development such as genetic disorders and cancer.
研究兴趣
论文共 245 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
BIOPHYSICAL JOURNALno. 1 (2024): 31-41
Zhaowei Liu, Pang Yen Wang, Julien Gros,Theo van Laar,Edo van Veen, Daniel Ramirez Montero,Humberto Sanchez, Nerea Murugarren, Katinka Ligthart, Milos Cvetkovic, Samson Glaser, Alessandro Costa,
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S27-S27
引用0浏览0引用
0
0
PLOS ONEno. 11 (2023)
Optics Communications (2023): 129548-129548
NUCLEIC ACIDS RESEARCHno. 8 (2023): 3770-3792
Nynke Dekker, Daniel Ramirez Montero,Humberto Sanchez,Zhaowei Liu,Edo van Veen,Theo van Laar,Belen Solano, John Diffley
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S43-S43
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn