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We are particularly interested in phosphoinositides in the nucleus. While it is still not clear how phosphoinositides are presented in the nucleus nor how they are controlled we and others have shown that their levels are changed in response to many different types of stimuli and that they are able to interact with and regulate proteins that are involved in nuclear functions such as transcription, mRNA processing and export and DNA conformation. One specific protein domain that appears to act as a nuclear receptor for phosphoinositides is called the PHD finger, which is a zinc finger that is present in proteins that are predominantly nuclear and that are involved in epigenetic signalling. Epigenetic signalling is essentially a mechanism by which environmental stimuli can impact on both short and long term gene transcriptional otput and thereby control cell fate decisions. DNA is wrapped up into nucleosomes by its interaction with histone proteins which then form higher order structures called chromatin. Chromatin forms at least seven different molecular structures which are differently associated with trasncriptional output. In essence epigenetic signaling involves the reversible enzymatic modification of DNA and of the histone proteins which appears to modify chromatin structure.
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EUROPEAN RESPIRATORY JOURNAL (2023)
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Nature communicationsno. 1 (2023): 1432
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ACS PHOTONICSno. 1 (2023): 42-52
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