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My research in the YCR Cancer Research Unit is now focused on the development and aetiology of human prostate cancer. Our overall approach has been to separate the tumour (and the corresponding normal tissue) into its cellular components, and to study the role played by different cell types. Of particular interest are the roles played by epithelial stem cells and the hormone-sensitive stromal cells within the tumour and normal prostate. We have compiled gene expression profiles for the various cell types using the Affymetrix platform, and have mined this data for genes and signalling pathways which affect cell fate. Much of our research is now concerned with hypothesis testing, based on the identified genes from this study, using complex multicellular models in vitro and developing xenograft models of the tumour. Clearly fate-altering genes also have therapeutic significance, and in a spin out company (Pro-Cure Therapeutics, founded in 2001) an associated research team are developing novel cancer stem cell treatments, based on the output of the YCR Research. There is a close collaboration between the two groups. As part of an International collaboration, coordinated from York, we are also developing novel biotherapies for prostate cancer, based on targeted and stealthed viral vectors, which allow us to either focus gene expression in specific cells within a tumour, or to engineer viruses to replicate only in tumour cells (oncolytics).
Research Interests
Papers共 312 篇Author StatisticsCo-AuthorSimilar Experts
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Rebecca Garnham,Daniel Geh,Ryan Nelson,Erik Ramon-Gil,Laura Wilson,Edward N. Schmidt,Laura Walker, Beth Adamson,Adriana Buskin,Anastasia C. Hepburn,Kirsty Hodgson, Hannah Kendall,
Communications Biologyno. 1 (2024): 1-13
crossref(2023)
crossref(2023)
crossref(2023)
Rebecca Garnham,Daniel Geh,Ryan Nelson,Erik Ramon-Gill,Laura Wilson,Edward N Schmidt,Laura Walker, Beth Adamson,Adriana Buskin,Anastasia Hepburn,Kirsty Hodgson, Hannah Kendall,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
crossref(2023)
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