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个人简介
Dr. Kleiman works at the intersection of public health, radiation research and ophthalmology, often using the eye as a model system to study the effects of environmental exposures, and radiation in particular, on human and animal health. For example, NASA and DOE funded research projects were designed to better understand ocular risks, and radiation cataract in particular, underlying eye exposure to low doses of different kinds of radiation, e.g. X-rays and high energy space radiation, (think cosmic rays). Related human research in Dr. Kleiman's laboratory estimates relative risk of radiation cataract in medical professionals such as interventional cardiologists and associated nursing personnel following occupational exposure to X-ray during fluoroscopic imaging procedures. A collaborative study with Ukrainian colleagues examines ocular radiation risk in Chornobyl accident cleanup workers. Recently, new projects have examined health risks posed by exposure to radiation, heavy metals and other environmental hazards in mice, voles and semi-domesticated dogs living within the Chornobyl exclusion zone. In other areas related to eye pathology, a NIEHS funded project investigates the potential relationship between arsenic exposure and cataract and recently reported significantly elevated arsenic concentrations in eye tissue. A recently funded NIEHS study examines the potentially carcinogenic heavy metal risks associated with e-cigarette use. At a mechanistic level, Dr. Kleiman applies molecular and biochemical approaches to examine how environmental toxins such as radiation, heavy metals or e-cigarette use causes DNA damage, misrepair and mutagenesis and how individual genetic determinants influence risk. Overall, these investigations help in formulating appropriate risk policies and aid in development of human exposure guidelines as well as having important therapeutic implications for radio- and/or chemo-sensitive subsets of the human population. Among other responsibilities, Dr. Kleiman is a technical cooperation expert for the International Atomic Energy Agency and serves on scientific committees of the National Council on Radiation Protection (NCRP) and the International Commission on Radiological Protection (ICRP).
研究兴趣
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Norman J. Kleiman,Elijah F. Edmondson,Michael M. Weil,Christina M. Fallgren,Adam King, Catherine Schmidt,Eric J. Hall
Life Sciences in Space Research (2024): 97-105
Scientific Reportsno. 1 (2024): 1-11
crossref(2024)
Canine medicine and geneticsno. 1 (2023): 1-14
Maximilian Gorlitz, Lennart Justen,Patrick J. Rochette,Manuela Buonanno,David Welch,Norman J. Kleiman,Ewan Eadie,Sachiko Kaidzu, William J. Bradshaw, Emilia Javorsky, Nigel Cridland,Anat Galor,
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