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Bio
My current work is focused on two main projects :
- Characterization of protective effect of human mesenchymal stem cells (hMSCs) on alveolar epithelial cells (AECs) exposed to hypoxia.
We have shown that hMSCs protect hypoxic AECs from epithelial-mesenchymal transition and from apoptosis through a paracrine mechanism (Uzunhan 2016; Bernard 2018). Thanks to proteomics, we are currently trying to characterize the precise signaling cascades modulated by hypoxia in AECs and to point out molecular mechanisms involved in anti-apoptotic, anti-oxidant and anti-fibrotic effects of hMSC conditioned medium on hypoxic AECs. This should help us to identify secreted factors involved in hMSCs cytoprotective effect.
- Innovative approaches for trachea repair and regeneration.
We are currently developing new approaches using hMSCs to improve tracheal regeneration from cryopreserved aortic graft (Martinod, JAMA 2018).
Research Interests
Papers共 20 篇Author StatisticsCo-AuthorSimilar Experts
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Thomas Gille,Morgane Didier,Cécile Rotenberg,Eva Delbrel,Dominique Marchant,Angela Sutton,Nicolas Dard,Liasmine Haine,Nicolas Voituron,Jean-François Bernaudin, Dominique Valeyre, Hilario Nunes,
Olivier Bernard,Florence Jeny,Yurdagül Uzunhan,Elisabetta Dondi, Rahma Terfous,Rabab Label,Angela Sutton, Jérôme Larghero,Valérie Vanneaux, Hilario Nunes,Emilie Boncoeur,Carole Planès,
Yurdaguel Uzunhan,Olivier Bernard,Dominique Marchant,Nicolas Dard,Valerie Vanneaux, Jerome Larghero,Thomas Gille,Christine Clerici, Dominique Valeyre, Hilario Nunes,Emilie Boncoeur,Carole Planes
Yurdagül Uzunhan,Olivier Bernard,Dominique Marchant,Nicolas Dard,Valérie Vanneaux, Jérôme Larghero,Thomas Gille,Christine Clerici,Dominique Valeyre, Hilario Nunes,Emilie Boncoeur,Carole Planès
semanticscholar(2016)
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Olivier Bernard,Florence Jeny,Elisabetta Dondy,Yurdagul Uzunhan, Shalini Sivarajah,Valérie Vanneaux, Jérôme Larghero, Hilario Nunes,Carole Planès,Nicolas Dard
Olivier A Bernard,F Jeny, E Dondi,Y Uzunhan, S Sivarajah,Valerie Vanneaux, Jerome Larghero, H Nunes,C Planes,N Dard
American journal of physiology. Lung cellular and molecular physiologyno. 11 (2014): L975-85
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