基本信息
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Career Trajectory
Bio
I was awarded an MRC career development fellowship in 1997, which led to the first crystal structures of RNA-aptamer-protein complexes, published in Nature Structural Biology. This interest and expertise in virus assembly has translated into current projects involving the development of virus-like particle (VLP) vaccines. These involve studies to generate a generic vaccine ‘scaffold’ and the development and characterisation of stabilised empty viral capsids as vaccine candidates for poliovirus and Enterovirus 71. I have demonstrated particular expertise on the RNA-dependent RNA polymerase (3D) in the replication of foot-and-mouth disease virus and the utility of RNA aptamers as inhibitors and molecular tools in vitro and in cells. This expertise in RNA aptamers has been applied to other systems, including selection and characterisation of the first RNA aptamers to both of the key oncoproteins of human papillomaviruses and strategies for topical RNA-based delivery into cells. As evidenced by my CV, I collaborate widely, having interdisciplinary collaborations internationally, within the UK and with Industry.
Research Interests
Papers共 160 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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Lee Sherry,Mohammad W Bahar,Claudine Porta,Helen Fox,Keith Grehan,Veronica Nasta,Helen M E Duyvesteyn,Luigi de Colibus,Johanna Marsian, Inga Murdoch,Daniel Ponndorf, Seong-Ryong Kim,
crossref(2024)
Natalie J Kingston,Joseph S Snowden,Keith Grehan, Philippa K Hall, Eero V Hietanen, Tim C Passchier,Stephen J Polyak,David J Filman,James M Hogle,David J Rowlands,Nicola J Stonehouse
bioRxiv : the preprint server for biology (2024)
The Journal of general virologyno. 7 (2023)
crossref(2023)
International journal of biological macromolecules (2023): 124519-124519
bioRxiv (Cold Spring Harbor Laboratory) (2023)
ChemMedChemno. 10 (2023)
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Author Statistics
#Papers: 162
#Citation: 4012
H-Index: 34
G-Index: 61
Sociability: 6
Diversity: 3
Activity: 32
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