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Genetics, epidemiology and cell biology of pulmonary hypertension
We study the molecular mechanisms underlying pulmonary arterial hypertension (PAH). In particular, our research focuses on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial PAH.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
Genetics, epidemiology and cell biology of pulmonary hypertension
We study the molecular mechanisms underlying pulmonary arterial hypertension (PAH). In particular, our research focuses on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial PAH.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
研究兴趣
论文共 732 篇作者统计合作学者相似作者
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Nature Communicationsno. 1 (2024): 1-13
J. Hong,L. Medzikovic, W. Sun,G. Ruffenach, B. Wong,C.J. Rhodes,A.J. Brownstein, L. Liang,L. Aryan, M. Li, A. Vadgama,Z. Kurt,
D95. SURVEYING THE ZOO: -OMICS FOR MECHANISTIC DISCOVERY IN PULMONARY VASCULAR DISEASE (2024)
Vascular Pharmacology (2024): 107381-107381
Amit Prabhakar,Rahul Kumar,Meetu Wadhwa,Prajakta Ghatpande, Jingkun Zhang,Ziwen Zhao,Carlos O. Lizama,Bhushan N. Kharbikar,Stefan Gräf,Carmen M. Treacy,Nicholas W. Morrell, Brian B. Graham,
Nature Cardiovascular Researchno. 7 (2024): 799-818
Vascular Pharmacology (2024): 107399-107399
Cardiovascular researchno. 7 (2024): 756-768
PULMONARY CIRCULATIONno. 1 (2024): e12346-e12346
American journal of respiratory and critical care medicineno. 12 (2024): 1477-1485
Circulationno. 21 (2023): 1606-1621
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