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Genetics, epidemiology and cell biology of pulmonary hypertension
We study the molecular mechanisms underlying pulmonary arterial hypertension (PAH). In particular, our research focuses on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial PAH.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
Genetics, epidemiology and cell biology of pulmonary hypertension
We study the molecular mechanisms underlying pulmonary arterial hypertension (PAH). In particular, our research focuses on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial PAH.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
Research Interests
Papers共 700 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Communicationsno. 1 (2024): 1-13
Jason Hong,Lejla Medzikovic, Wasila Sun, Brenda Wong,Grégoire Ruffenach,Christopher J Rhodes,Adam Brownstein, Lloyd L Liang,Laila Aryan, Min Li, Arjun Vadgama,Zeyneb Kurt,
Circulation (2024)
Vascular Pharmacology (2024): 107381-107381
Amit Prabhakar,Rahul Kumar,Meetu Wadhwa,Prajakta Ghatpande, Jingkun Zhang,Ziwen Zhao,Carlos O. Lizama,Bhushan N. Kharbikar,Stefan Gräf,Carmen M. Treacy,Nicholas W. Morrell, Brian B. Graham,
Nature Cardiovascular Researchno. 7 (2024): 799-818
Vascular Pharmacology (2024): 107399
Cardiovascular researchno. 7 (2024): 756-768
PULMONARY CIRCULATIONno. 1 (2024): e12346-e12346
PULMONARY CIRCULATIONno. 1 (2024): e12353-e12353
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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Author Statistics
#Papers: 706
#Citation: 32977
H-Index: 95
G-Index: 168
Sociability: 8
Diversity: 3
Activity: 255
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