基本信息
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职业迁徙
个人简介
Research Interests
We seek to learn how cells control the translation and stability of mRNA transcripts and understand the role of this dynamic regulation in maintaining homeostasis and adapting to changing environments. Cells tightly control which genes they express as proteins, and the amount of each protein they make, and post-transcriptional regulation can modulate gene expression based on cellular needs and extracellular conditions. Indeed, rapid reprogramming of protein synthesis in dynamic environments often depends on modulating the translation and stability of existing transcripts. This regulation depends on mRNA-binding proteins, which are as numerous as sequence-specific transcription factors, suggesting a pervasive role for post- transcriptional regulation in cell physiology. We are thus very interested in a genetic and molecular understanding of these RNA-binding proteins, and much of our work focuses on developing comprehensive and high-throughput techniques for elucidating post-transcriptional regulatory networks.
We seek to learn how cells control the translation and stability of mRNA transcripts and understand the role of this dynamic regulation in maintaining homeostasis and adapting to changing environments. Cells tightly control which genes they express as proteins, and the amount of each protein they make, and post-transcriptional regulation can modulate gene expression based on cellular needs and extracellular conditions. Indeed, rapid reprogramming of protein synthesis in dynamic environments often depends on modulating the translation and stability of existing transcripts. This regulation depends on mRNA-binding proteins, which are as numerous as sequence-specific transcription factors, suggesting a pervasive role for post- transcriptional regulation in cell physiology. We are thus very interested in a genetic and molecular understanding of these RNA-binding proteins, and much of our work focuses on developing comprehensive and high-throughput techniques for elucidating post-transcriptional regulatory networks.
研究兴趣
论文共 9 篇作者统计合作学者相似作者
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Jungwoo Wren Kim, Adeline J. H. Yong,Ted M. Dawson,Valina L. Dawson,Yuh-Nung Jan,Nicholas T. Ingolia
biorxiv(2022)
Henri A Galez,Françoise M Roelants, Sarah M Palm, Kendra K Reynaud,Nicholas T Ingolia,Jeremy Thorner
biorxiv(2021)
Cell Reportsno. 1 (2016): 1-10
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D-Core
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