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Our research program focuses on mechanisms by which metabolic therapy manages chronic diseases such as epilepsy, neurodegenerative lipid storage diseases, and cancer. The metabolic therapies include caloric restriction, fasting, and ketogenic diets. Our approach is based on the idea that compensatory metabolic pathways are capable of modifying the pathogenesis of complex diseases. Global shifts in metabolic environment can neutralize molecular pathology. In the case of cancer, these therapies target and kill tumor cells while enhancing the physiological health of normal cells. The neurochemical and genetic mechanisms of these phenomena are under investigation in novel animal models and include the processes of inflammation, cellular physiology, angiogenesis, and lipid biochemistry.
Research Interests
Papers共 721 篇Author StatisticsCo-AuthorSimilar Experts
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medRxiv : the preprint server for health sciences (2024)
Research square (2024)
Fatemeh Seifar,Edward J. Fox,Anantharaman Shantaraman,Yue Liu,Eric B. Dammer,Erica Modeste,Duc M. Duong,Luming Yin, Adam N. Trautwig,Qi Guo, Kaiming Xu,Lingyan Ping,
bioRxiv the preprint server for biology (2024)
SCIENCE TRANSLATIONAL MEDICINEno. 730 (2024): eadf9735-eadf9735
Nikolaos P Daskalakis,Artemis Iatrou,Chris Chatzinakos,Aarti Jajoo,Clara Snijders,Dennis Wylie, Christopher P DiPietro, Ioulia Tsatsani,Chia-Yen Chen,Cameron D Pernia,Marina Soliva-Estruch,Dhivya Arasappan,
Science (New York, N.Y.)no. 6698 (2024): eadh3707-eadh3707
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 6 (2024): 4043-4065
Research square (2024)
biorxiv(2024)
Current Tissue Microenvironment Reportspp.1-9, (2024)
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