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Bio
Restifo is a pioneer in the field of cancer immunotherapy with a focus on the use of T cells in the treatment of malignancy. One of Dr. Restifo's major discoveries is that CD8+ T cells experience a stereotypical maturational program. His early work was focused on discovering how tumor cells can escape from T cell recognition. He went on to characterize the mechanisms underlying why T cells survive and expand better after lymphodepletion. His most recent efforts include a focus on how elements – literally from the periodic table – influence cancer immunity. These include work on how oxygen can inhibit anti-tumor immunity and how potassium ions from dying cancer cells can shut down the anti-tumor response.
Successful treatment of patients with cancer is the goal of his laboratory, and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming. Basic aspects of tumor and T cell immunology inform novel therapeutic interventions in the clinic.
Restifo and his research team have made contributions to the fields of adoptive cell transfer tumor immune-escape, virally encoded cancer vaccines, adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory CD8+ T cells.
Successful treatment of patients with cancer is the goal of his laboratory, and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming. Basic aspects of tumor and T cell immunology inform novel therapeutic interventions in the clinic.
Restifo and his research team have made contributions to the fields of adoptive cell transfer tumor immune-escape, virally encoded cancer vaccines, adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory CD8+ T cells.
Research Interests
Papers共 638 篇Author StatisticsCo-AuthorSimilar Experts
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The Journal of experimental medicineno. 5 (2024)
Raul Vizcardo, Yin Huang,Jessica Fioravanti,Takuya Maeda,Naritaka Tamaoki,Yasuhiro Yamazaki, Burak Kutlu,Kriti Bahl, Biao Wang, Zheng Zhong,Shobha Potluri,Nicholas P. Restifo,
Cancer Researchno. 6_Supplement (2024): 6593-6593
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Biao Wang,Nicholas Restifo,Raul Vizcardo,Gary Lee,Kriti Bahl,Shobha Potluri, Zheng Zhong, Yin Huang,Takuya Maeda,Jessica Fioravanti,Naritaka Tamaoki, Burak Kutlu,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Author Statistics
#Papers: 630
#Citation: 103080
H-Index: 155
G-Index: 318
Sociability: 8
Diversity: 0
Activity: 1
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