基本信息
views: 211
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research
The Morrell laboratory is studying the molecular mechanisms underlying pulmonary arterial hypertension. In particular our research is focussed on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial pulmonary arterial hypertension (PAH). In addition we are leading large national and international studies to identify novel genetic drivers of PAH and chronic thromboembolic pulmonary hypertension.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
The Morrell laboratory is studying the molecular mechanisms underlying pulmonary arterial hypertension. In particular our research is focussed on how mutations in the bone morphogenetic protein type II receptor (BMPR-II), a receptor member of the transforming growth factor-beta superfamily, cause familial pulmonary arterial hypertension (PAH). In addition we are leading large national and international studies to identify novel genetic drivers of PAH and chronic thromboembolic pulmonary hypertension.
Our research is revealing how BMPR-II mutation leads to dysfunctional signalling, gene transcription and vascular cell biology. This work has also revealed a broader role for BMPR-II in angiogenesis, inflammation, iron metabolism and innate immunity.
Research Interests
Papers共 708 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Cardiovascular researchno. 7 (2024): 756-768
Nature Communicationsno. 1 (2024): 1-13
Vascular Pharmacology (2024): 107381-107381
Kayleigh Griffiths,Roger J Grand, Ian Horan, Michelangelo Certo, Ross C Keeler,Claudio Mauro,Chih-Chung Tseng,Iain Greig,Nicholas W Morrell, Matteo Zanda,Michael P Frenneaux,Melanie Madhani
Vascular pharmacology (2024): 107399-107399
PULMONARY CIRCULATIONno. 1 (2024): e12346-e12346
James Liley,Michael Newnham,Marta Bleda,Katherine Bunclark,William Auger,Joan Albert Barbera, Harm Bogaard, Marion Delcroix,Timothy M Fernandes,Luke Howard,David Jenkins,Irene Lang,
American journal of respiratory and critical care medicineno. 12 (2024): 1477-1485
Jason Hong,Brenda Wong, Christopher J Rhodes,Zeyneb Kurt,Tae-Hwi Schwantes-An,Elizabeth A Mickler,Stefan Gräf,Mélanie Eyries,Katie A Lutz,Michael W Pauciulo,Richard C Trembath, David Montani,
bioRxiv the preprint server for biology (2023)
Circulationno. 21 (2023): 1606-1621
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn