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职业迁徙
个人简介
Virus is one of the largest global health concerns. The ability of virus to rapidly evolve underlies the challenge to achieve a virus-free world. The two major problems are 1) immune evasion, which can lead to vaccine escape, and 2) host jump, which can lead to pandemic. Fortunately, not all viral mutations have a deleterious consequence to public health. Most viral mutations disrupt protein functions that are essential in the virus life cycle. Therefore, a significant portion of the viral genome is under strong evolutionary constraints. Our research interest is to characterize virus evolution, including both positive selection pressures (immune evasion and host adaptation) and negative selection pressures (virus-host molecular interactions). While our main focus has been on influenza virus, we occasionally work on other viruses such as HIV, HCV, and SARS-CoV-2
Research Interests
Research Topics
Bioinformatics, Host-Pathogen Interactions, Molecular Evolution, Molecular Immunology, Protein Structure, Virology
Disease Research Interests
Cancer, Infectious Diseases
研究兴趣
论文共 143 篇作者统计合作学者相似作者
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Timothy J C Tan, Abhishek K Verma, Abby Odle, Ruipeng Lei, David K Meyerholz,Kenneth A Matreyek, Stanley Perlman, Lok-Yin Roy Wong,Nicholas C Wu
Proceedings of the National Academy of Sciences of the United States of Americano. 15 (2024): e2317222121-e2317222121
TRENDS IN IMMUNOLOGYno. 1 (2024): 11-19
Ruipeng Lei,Enya Qing,Abby Odle,Meng Yuan,Timothy J C Tan, Natalie So,Wenhao O Ouyang,Ian A Wilson,Tom Gallagher,Stanley Perlman,Nicholas C Wu, Lok-Yin Roy Wong
bioRxiv : the preprint server for biology (2023)
Cell Reportsno. 10 (2023): 113356-113356
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Biophysical journalno. 3S1 (2023): 448a-449a
Yiquan Wang,Huibin Lv,Ruipeng Lei, Yuen-Hei Yeung, Ivana R Shen, Danbi Choi,Qi Wen Teo,Timothy J C Tan, Akshita B Gopal,Xin Chen, Claire S Graham,Nicholas C Wu
bioRxiv : the preprint server for biology (2023)
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