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Research interests
The broad focus of my lab is to understand at the molecular level how bacteria are able to evolve so rapidly. In a little over half a century, strains of 'golden staph' (Staphylococcus aureus) have become resistant to most useful antibiotics. As a result, this bacterial pathogen remains a major cause of hospital-acquired infections around the world, and it is increasingly a cause of serious infections in the general community. In most cases, MRSA (methicillin-resistant S. aureus) has become resistant by capturing pre-existing resistance genes and integrating them into its genome.
To understand the details of how these genes are captured, regulated, inherited, and spread by S. aureus, we undertake research on the following topics:
Molecular biology of mobile DNA, such as multiresistance plasmids, transposons and insertion sequence (IS) elements
DNA replication and segregation
Gene transfer mechanisms such as conjugation (DNA transmission via cell-to-cell contact)
Regulation of gene expression
The broad focus of my lab is to understand at the molecular level how bacteria are able to evolve so rapidly. In a little over half a century, strains of 'golden staph' (Staphylococcus aureus) have become resistant to most useful antibiotics. As a result, this bacterial pathogen remains a major cause of hospital-acquired infections around the world, and it is increasingly a cause of serious infections in the general community. In most cases, MRSA (methicillin-resistant S. aureus) has become resistant by capturing pre-existing resistance genes and integrating them into its genome.
To understand the details of how these genes are captured, regulated, inherited, and spread by S. aureus, we undertake research on the following topics:
Molecular biology of mobile DNA, such as multiresistance plasmids, transposons and insertion sequence (IS) elements
DNA replication and segregation
Gene transfer mechanisms such as conjugation (DNA transmission via cell-to-cell contact)
Regulation of gene expression
研究兴趣
论文共 77 篇作者统计合作学者相似作者
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Alvina Sarosh,Stephen M Kwong,Slade O Jensen, Faith Northern,William G Walton, Thomas C Eakes,Matthew R Redinbo,Neville Firth,Krystle J McLaughlin
Plasmid (2023): 102708-102708
Proceedings of the National Academy of Sciences of the United States of Americano. 35 (2021): 2104685118
Jessica Sayers, Phillip M T Karpati,Nicholas J Mitchell,Anna M Goldys, Stephen M Kwong,Neville Firth,Bun Chan,Richard J Payne
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