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个人简介
For over 20 years, Dr. Stella has studied the molecular mechanism and therapeutic value of cannabinoid-based molecules (including of phyto-cannabinoids produced by the plant, synthetic cannabinoids developed in the laboratory and endocannabinoids produced by cells). These cannabinoid-based molecules could help for the treatment of devastating brain diseases, including brain cancers and epilepsy. The initial work led to the discovery of both the prominent endocannabinoid, 2-arachidonylglycerol (2-AG), in the brain, and its degrading enzyme, ABHD6, that controls 2-AG signaling in brain and peripheral tissues. The more recent work led to the development of small molecule (ST-compounds) that destabilize microtubules and kill cancer cells through a novel mechanism. ST compounds pass the blood brain barrier and are being developed for the treatment glioblastomas and brain metastases.
研究兴趣
论文共 208 篇作者统计合作学者相似作者
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Juan Jesus Vicente, Kainat Khan, Grant Tillinghast,José L. McFaline-Figueroa,Yasemin Sancak,Nephi Stella
Journal of Translational Medicineno. 1 (2024): 1-20
British journal of pharmacologyno. 15 (2024): 2459-2477
Anthony English, Fleur Uittenbogaard,Alexa Torrens,Dennis Sarroza, Anna Veronica Elizabeth Slaven,Daniele Piomelli,Michael R. Bruchas,Nephi Stella,Benjamin Bruce Land
ELIFE (2024)
Anthony English, Fleur Uittenbogaard,Alexa Torrens, Dennis Sarroza, Anna Veronica Elizabeth Slaven,Daniele Piomelli,Michael R Bruchas,Nephi Stella,Benjamin Bruce Land
crossref(2024)
Michael Wang, Marcus Faust, Scott Abbott, Vikrant Patel, Eric Chang,John I. Clark,Nephi Stella,Paul J. Muchowski
medRxiv (Cold Spring Harbor Laboratory) (2024)
David Marcus, Emma Seth, Sabrina Hwang, Rachel Oomen,Anthony English,Christian Pedersen,Avery Hunker,Azra Suko,Yulong Li,Nephi Stella,Larry Zweifel,Michael Bruchas
NEUROPSYCHOPHARMACOLOGY (2023): 484-484
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CANNABIS AND CANNABINOID RESEARCH (2023)
Allison E. Cherry,Brian R. Haas, Alipi V. Naydenov,Susan Fung,Cong Xu, Katie Swinney,Michael Wagenbach, Jennifer Freeling,David A. Canton,Jonathan Coy, Eric A. Horne, Barry Rickman,
crossref(2023)
Cannabis and Cannabinoid Research (2023)
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