基本信息
浏览量:3
职业迁徙
个人简介
Research Summary
Research in our laboratory investigates how neurons acquire distinct identities and form precise connections in the developing cerebral cortex, a part of the brain involved in a variety of higher cognitive, emotional, sensory, and motor functions. We also study how these developmental processes have changed during evolution and in human disorders. We study these problems for primarily two reasons. The first reason is to explore what it is about our brain that makes us human. The most important distinction between humans and other species is largely thought to reside in the unique features of human brain development, especially the way in which intricate neuronal circuits of the cerebral cortex are wired. The second reason for this research is to understand why humans suffer from certain brain diseases. The emergence of intricate neuronal circuits has given us remarkable cognitive abilities, but may have also increased our susceptibility to disorders such as autism and schizophrenia.
An important element of our research is the integration of complementary approaches at the interface of developmental neurobiology, molecular biology, comparative genomics, and genetics. To achieve this, we combine:
Analyses of evolutionarily conserved developmental mechanisms using the genetically tractable mouse model
Comparative analyses to identify human-specific features of brain development
Genetic and molecular analyses of disorders of human cognitive development
Research in our laboratory investigates how neurons acquire distinct identities and form precise connections in the developing cerebral cortex, a part of the brain involved in a variety of higher cognitive, emotional, sensory, and motor functions. We also study how these developmental processes have changed during evolution and in human disorders. We study these problems for primarily two reasons. The first reason is to explore what it is about our brain that makes us human. The most important distinction between humans and other species is largely thought to reside in the unique features of human brain development, especially the way in which intricate neuronal circuits of the cerebral cortex are wired. The second reason for this research is to understand why humans suffer from certain brain diseases. The emergence of intricate neuronal circuits has given us remarkable cognitive abilities, but may have also increased our susceptibility to disorders such as autism and schizophrenia.
An important element of our research is the integration of complementary approaches at the interface of developmental neurobiology, molecular biology, comparative genomics, and genetics. To achieve this, we combine:
Analyses of evolutionarily conserved developmental mechanisms using the genetically tractable mouse model
Comparative analyses to identify human-specific features of brain development
Genetic and molecular analyses of disorders of human cognitive development
研究兴趣
论文共 206 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Biological Psychiatry Global Open Scienceno. 4 (2024): 100321-100321
Xoel Mato-Blanco,Suel-Kee Kim, Alexandre Jourdon,Shaojie Ma,Andrew T N Tebbenkamp,Fuchen Liu, Alvaro Duque,Flora M Vaccarino,Nenad Sestan,Carlo Colantuoni,Pasko Rakic, Gabriel Santpere,
bioRxiv : the preprint server for biology (2024)
Prashant S Emani,Jason J Liu,Declan Clarke,Matthew Jensen,Jonathan Warrell,Chirag Gupta, Ran Meng,Che Yu Lee,Siwei Xu, Cagatay Dursun,Shaoke Lou, Yuhang Chen,
bioRxiv : the preprint server for biologyno. 6698 (2024): eadi5199-eadi5199
Mary Kate P Joyce, Tsvetoslav G Ivanov,Fenna Krienen, Jude Mitchell,Shaojie Ma, Wataru Inoue,Anirvan P Nandy,Dibyadeep Datta, Alvaro Duque,Jon I Arellano, Rahul Gupta,Guillermo Gonzalez-Burgos,
biorxiv(2024)
Brain : a journal of neurologyno. 4 (2024): 1553-1570
Shreyash Sonthalia, Guangyan Li, Xoel Mato Blanco,Alex Casella,Jinrui Liu,Genevieve Stein-O'Brien,Brian Caffo,Ricky S Adkins,Joshua Orvis,Ronna Hertzano,Anup Mahurkar,Jesse Gillis,
bioRxiv : the preprint server for biology (2024)
Katherine Fleck,Victor Luria, Nitanta Garag,Amir Karger, Trevor Hunter, Daniel Marten,William Phu, Kee-Myoung Nam,Nenad Sestan,Anne H O'Donnell-Luria,Jelena Erceg
bioRxiv : the preprint server for biology (2024)
Cindy Wen,Michael Margolis,Rujia Dai,Pan Zhang,Pawel F Przytycki, Daniel D Vo,Arjun Bhattacharya,Nana Matoba, Miao Tang,Chuan Jiao,Minsoo Kim,Ellen Tsai,
Science (New York, N.Y.)no. 6698 (2024): eadh0829-eadh0829
The Journal of experimental medicineno. 4 (2024)
Scientific datano. 1 (2023): 813-813
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn