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My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.
Research Interests
Papers共 591 篇Author StatisticsCo-AuthorSimilar Experts
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BLOOD ADVANCESno. 3 (2024): 667-680
Anthony D Sung,Thuy Koll,Shannon H Gier,Alessandro Racioppi, Griffin White,Meagan Lew, Marcia Free, Priyal Agarwal,Lauren M Bohannon,Ernaya J Johnson,Bharathi Selvan,Daria V Babushok,
Transplantation and cellular therapyno. 4 (2024): 415.e1-415.e16
GUT MICROBESno. 1 (2024): 2333748-2333748
Transplantation and Cellular Therapyno. 3 (2023): 179e1-179e10
Emily Smith,Esther Majaliwa,Cesia Cotache Condor,Hannah Rice, Yotham Gwanika,Julia Canick,Nelson Nelson Chao, Kristen Schroder,Henry Rice,Catherine Catherine Staton,Blandina Mmbaga
PEDIATRIC BLOOD & CANCERno. 9 (2023): S511-S511
JCI INSIGHTno. 11 (2023)
W. June Brickey,David L. Caudell,Andrew N. Macintyre,John D. Olson, Yanwan Dai,Sirui Li,Gregory O. Dugan,J. Daniel Bourland, Lisa M. O'Donnell,Janet A. Tooze, Guannan Huang,Shuangshuang Yang,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 50 (2023)
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