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个人简介
In our research we use experimental and computational methods to understand the cellular mechanisms that give rise to drug resistance in tumors and we use engineering methods to design therapeutic strategies to overcome resistance in tumors.
Current Research
To date the major advances of our group have been:
determination of the mechanisms that control the localization of therapeutic bacteria in tumors;
development of therapeutic bacteria that secrete an anti-cancer protein and dramatically increase survival in mice;
quantification of the effects of spatial heterogeneity on tumor metabolism, cell survival, and cell cycle progression;
development of computation tools to analyze the interactions of therapeutics with tumors; and
demonstration that the properties of nanoparticles can be tuned to enhance tumor targeting.
Current Research
To date the major advances of our group have been:
determination of the mechanisms that control the localization of therapeutic bacteria in tumors;
development of therapeutic bacteria that secrete an anti-cancer protein and dramatically increase survival in mice;
quantification of the effects of spatial heterogeneity on tumor metabolism, cell survival, and cell cycle progression;
development of computation tools to analyze the interactions of therapeutics with tumors; and
demonstration that the properties of nanoparticles can be tuned to enhance tumor targeting.
研究兴趣
论文共 40 篇作者统计合作学者相似作者
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Shradha Khanduja, Shoshana M.K. Bloom,Vishnu Raman, Chinmay P. Deshpande, Christopher L. Hall,Neil S. Forbes
Frontiers in Immunology (2023): 1228532-1228532
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user-5f8cf7e04c775ec6fa691c92(2016)
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Proceedings of the National Academy of Sciencesno. 11 (2015): 3457-3462
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