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After a PhD in molecular microbiology and a postdoc position in London, I have been recruited in 1996 as an assistant professor at the « Université de Nancy » in France. I obtained a professor position in 2011 at the newly created Université de Lorraine.
I am currently involved in two main research projects. One concerns the search and the characterization of Integrative Conjugative Elements (ICEs) and of Integrative Mobilizable Elements (IMEs) in Gram positive bacterial genomes. We have previously demonstrated the high prevalence and diversity of ICEs and IMEs within streptococcal genomes. At the moment, we are developing a bioinformatic tool for the automated prediction of ICEs and IMEs within the genomes of Firmicutes (external collaborators : H. Chiapello and T Lacroix, MaIAGE INRA Jouy-en-Josas). My second research project aims at deciphering at the molecular level, the mechanism of transfer of an ICE (ICESt3 as a model). Our current work is centered on the structure-function analysis of proteins involved in the transfer of ICESt3 (external collaborators : I Chauvot de Beauchene LORIA Nancy - F Favier and C Didierjean CRM2 Nancy). We have already characterized one enzyme involved in the early step of the conjugation. Together with collegues from the Loria (MD Devignes) and from the LPCT (C Chipot and F Dehez) in Nancy, we are developing conjugation inhibitors.
Previously, I focused an important part of my work on the characterization of genes and proteins involved in the stress responses of Streptococcus thermophilus (thermal and oxydative stresses).
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Methods in molecular biology (Clifton, N.J.) (2024): 79-91
Antibiotics (Basel, Switzerland)no. 3 (2023): 579-579
crossref(2022)
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