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The ultimate goal of the research in our laboratory is the structure-based design of novel, therapeutically useful antibiotics and inhibitors of antibiotic-resistance mechanisms. To achieve this goal we use a combination of x-ray crystallography, molecular modelling, molecular docking and molecular biology in collaboration with medicinal chemistry to engineer drugs that specifically interact with and disable critical bacterial target proteins. Specific areas of interest include:
Bacterial beta-lactamases are enzymes which cleave the four membered beta-lactam ring of the classic family of antibiotics known as the penicillins and cephalosporins.
Design of novel antibiotics will be pursued through the structural analysis of bacterial enzymes which catalyze crucial reactions in the life-cycle of the bacteria.
Bacterial beta-lactamases are enzymes which cleave the four membered beta-lactam ring of the classic family of antibiotics known as the penicillins and cephalosporins.
Design of novel antibiotics will be pursued through the structural analysis of bacterial enzymes which catalyze crucial reactions in the life-cycle of the bacteria.
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Mathew P Kirby, Ciara Stevenson,Liam J Worrall,Yihang Chen,Christina Young, Jisoo Youm,Natalie C J Strynadka,Douglas W Allan,Eric Jan
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