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个人简介
I have worked in the glycoscience field during my entire academic scientific career. I focused on O-linked glycosylation especially GalNAc-type glycosylation and developed a comprehensive O-glycoproteome strategy by use of precise gene editing and mass spectrometry technologies. This approach provided comprehensive site mapping of the O-glycoproteome, and discovery of site-specific O-glycosylation regulated by distinct GalNAc-transferases. Recently, I developed a comprehensive and high-throughput platform for designing Cas9 gene targeting platform and developed a comprehensive validated CRISPR library targeted to all human glycosyltransferases (GlycoCRISPR). This tool enabled me to target all known human glycosyltransferase genes and generate comprehensive glycoengineered isogenic cell libraries with different glycosylation capacities (GlycoDisplay). This library serves as the first cell-based glycan array to display the human glycome in the natural context of the complete glycoconjugate structure and cell membrane.
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论文共 78 篇作者统计合作学者相似作者
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Yohei Tsukamoto, Natsumi Tsukamoto, Wataru Saiki,Yuko Tashima,Jun-Ichi Furukawa,Yasuhiko Kizuka,Yoshiki Narimatsu,Henrik Clausen,Hideyuki Takeuchi,Tetsuya Okajima
Biochemical and biophysical research communications (2024): 149610-149610
Yoshiki Narimatsu,Christian Büll, Víctor Taleb,Qinghua Liao,Ismael Compañón, David Sánchez-Navarro,Fabien Durbesson,Renaud Vincentelli,Lars Hansen,Francisco Corzana, Carme Rovira,Bernard Henrissat,
Yohei Tsukamoto,Kazuhiro Aoki,Yoshiki Narimatsu,Yusuke Urata,Wataru Saiki,Michael Tiemeyer,Henrik Clausen, Yuki Kurebayashi,Akira Minami, Tadanobu Takahashi,Tetsuya Okajima,Hideyuki Takeuchi
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Zhen Li,Lucia Di Vagno,Aisling Ni Cheallaigh,Douglas Sammon,David C. Briggs, Nara Chung, Vincent Chang,Keira E. Mahoney,Anna Cioce, Lloyd D. Murphy,Yen-Hsi Chen,Yoshiki Narimatsu,
biorxiv(2023)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 31 (2023)
Daniel Madriz Sørensen,Christian Büll, Thomas D Madsen,Erandi Lira-Navarrete,Thomas Mandel Clausen,Alex E Clark, Aaron F Garretson,Richard Karlsson, Johan F A Pijnenborg,Xin Yin,Rebecca L Miller,Sumit K Chanda,
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