基本信息
浏览量:35
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Prof. Narcisa M. Quiles is a Board Certified Immunologist with 5 Research periods (Sexenios, 2021), 1 Transfer Sexenio (2017), and 15 years of teaching experience (3 quinquenios). She has successfully directed 3 Ph.D. students (2 international Doctorate program). She has authored 3 chapters and 38 publications. Total cites: 1192. H index 15. Among them: J Immunology (first author, Predoctoral), Nature Cell Biol (first author, Postdoc.) Plos Pathogens (PI, corresponding); Cell Host and Microbe (Collaboration).
Residency and Predoctoral Period. After scoring 4/629 in a national exam (BIR) she joined the residency program and publishes 11 papers (7 in D1), such as a J of Immunology (1st author,) a very prestigious journal, and she obtained 2 postdoctoral national fellowships (FIS, MEC).
Postdoctoral Period (Raif S. Geha Lab., Immunol. Div., Children´s Hosp. Harvard Medical School), She studied the “Wiskott-Aldrich syndrome” and lead the setting-up of sophisticated techniques (microinjection, microscopy), introduced new lines (cortactin) and collaborations (WAVE, Verprolin). She obtained high-quality results that were published as lead author in Nature Cell Biology y Mol Cel Biol. There it is described WIP as a regulator of filopodia through N-WASP-Cdc-42, a structure that subtends many immunological processes. The second study connects the two families of actin nucleators (WASPs and Cortactin), and proposes a model of regulation of the later by Ser/Tyr phosphorylation, reviewed in several occasions (PMIDs:15817388, 15670811, 21655441), and applied to other pathways (adhesion, invadopodia PMID: 18768925, 17343955, actin polymerization 17606906, 21079800). This study is the foundation of her independent lines of research as a PI. In recognition, she obtained several awards: New Investigators Award (CIS), Paul A. Dobuler Fundation Prize and the Children´s Hospital award.
PI Period. After scoring position 5th (national Biomedicine committee), she joined the University Complutense with a “Ramón y Cajal” research contract (Sept. 2004, Microbiology Dpt.) with the aim of perfecting her skills in Host/ Pathogen interaction models (EPEC). As PI, she attained a prestigious Marie Curie Internacional Reintegración grant (2006-8), and a FIS grant (2007-9). She establishes novel lines of research focusing on Cortactin. She was evaluated as an I3 remarkable researcher (Science Ministry). She obtained a 2nd FIS grant (2010-2; 54.000€) and publishes 10 articles, 5 as corresponding author, including a prestigious Plos Pathogens (D1) and a Cell Host and Microbe (D1). The team made important discoveries about the mechanism of cell adhesion by the pathogenic bacteria EPEC, dissecting cortactin contribution and describing the first and sole inhibitors (Crk adaptors) of the major pathway. Together the findings help to reinterpret the role of Nck in the major pathway. In addition, a new cortactin-FAK pathway is described in cell adhesion and Helicobacter infection, which is relevant for cancer treatment (PMID: 22378044).
The researcher acquired international recognition and is invited to the WP7 closure meeting of the Marie Curie actions, and she is distinguished as a “successful career progression example” in From Face to Face (doi: 10.2777/87638). She is invited to two infect-ERA calls in EPEC (Ilan Rosenshine) and Salmonella (M. Hensel), both of which unfortunately are not finally awarded. In spite of the recognition and good productivity level of her publications, she is no longer supported neither by the ISCIII nor by the MINECO research programs and remains 5 years without funding (2013-7), which destroys her scientific progression. The researcher persists and in 2018 starts a new grant period as PI (SAF2017-82967-R) and obtained a Fulbright-MEC 6 months visit to the NIH.
The researcher has acquired international recognition, as proven by the multidisciplinary international collaborations established (Walter Beron/ Coxiella, Ana Cárdenas/ exocitosis, Stefen Backert/ Helicobacter, Albert Selva/ Miastenia-Miositis (in progress)). She joints-in editorial committees is a reviewer and collaborates with certification companies. She is a member of scientific forums (Cytoskeletal European Forum, LACER), participates actively in the promotion of science to society, with relevant international contributions (news, INMUNOMEDIA, RNE COVID-19, #STEMitas). She is the lead of transfer-of-knowledge for an antimicrobial herbal tea, (in progress). She has been the tutor of graduate students (12 Master Thesis), Ph.D. students, and under-contract personnel, contributing to their career progression in the industry (Nieto-Pelegrín/ PTC Therapeutics, Meiler/ GSK), and in academia. To end, the researcher has had an outstanding career path as Harvard Fellow e Instructor, Ramón y Cajal-I3 researcher, Marie Curie grantee, and Fulbright Scholar, and she has demonstrated that with the appropriate grant support she can be an excellent researcher.
研究兴趣
论文共 51 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Reda Mohamed-Salem,Carmina Rodríguez Fernández,Elvira Nieto-Pelegrín, Beatriz Conde-Valentín,Angel Rumbero,Narcisa Martinez-Quiles
A. Corell, C. Martin Alonso, J. C. Zarzuela, L. A. Sanz, J. C. Aragon, J. M. Sempere, D. Hudrisier,P. Rodrigues Santos,S. Alvarez Alvarez,V Arnaiz,M. J. Verdu Perez,L. M. Regueras Santos,
引用0浏览0引用
0
0
引用0浏览0引用
0
0
TISSUE ANTIGENSno. 5 (2015): 397-397
引用8浏览0引用
8
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn