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Bio
Her main research focus is in the area of liver graft injury and cancer recurrence after transplantation utilizing an integrated basic, clinical and translational approach. She has developed a series of novel animal models to mimic liver graft injury and cancer recurrence. She is the first to establish a rat orthotopic liver transplantation model using small-for-size graft in Hong Kong. These models have been extensively introduced into the investigation of liver transplantation. For example, the correlation between transient portal hypertension resulted from excessive portal flow and hepatic sinusoidal damage of small-for-size liver graft was first revealed in animal model she established and the finding was subsequently validated in a series of her clinical studies. The further studies for the mechanism of graft injury and novel treatments were also conducted in animal models she established. She is first to report the significance of small-for-size liver graft injury on tumor recurrence after transplantation in the world and further to explore the molecular mechanisms of inflammatory response in acute phase and tumor invasiveness in late phase. In parallel, she has focused on the molecular mechanisms involved inflammation and cancer progression, together with the development of novel therapies for cancer metastasis. In addition, she has also established the research platform for in vivo small animal imaging modalities, which are widely applied in various research fields in the Faculty and beyond.
Research Interests
Papers共 415 篇Author StatisticsCo-AuthorSimilar Experts
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Yunong Xie, Haofeng Wu, Yimiao He, Linglin Liu, Ianto Bosheng Huang,Lei Zhou, Cheuk-Yin Lin, Rainbow Wing-Hei Leung,Jia-Jian Loh,Terence Kin-Wah Lee,Jin Ding,Kwan Man,
Oscar Hou In Chou, Jing Ning,Raymond Ngai Chiu Chan,Cheuk To Chung,Helen Huang,Kenrick Ng,Edward Christopher Dee,Sharen Lee,Apichat Kaewdech, Ariel K. Man Chow,Nancy Kwan Man,Tong Liu,
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORKno. 2D (2024)
Cancer Imagingno. 1 (2024): 1-10
CANCER IMAGINGno. 1 (2024)
Cancer Researchno. 6_Supplement (2024): 2703-2703
Zhiwu Tan,Mei Sum Chiu, Ming Yue,Hau Yee Kwok, Man Ho Tse,Yang Wen,Bohao Chen,Dawei Yang,Dongyan Zhou,You-Qiang Song,Kwan Man,Zhiwei Chen
JOURNAL OF LEUKOCYTE BIOLOGYno. 4 (2024): 633-646
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONALno. 3 (2024): 257-264
TRANSPLANTATIONno. 9 (2023): 283-284
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Neuro-Oncology (2023)
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