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Sirtuins in Cardiovascular diseases–
Our lab studies Sirtuins, a family of histone deacetylases. Mammalian genome encodes seven Sirtuin isoforms (SIRT1-SIRT7), which differ in their structures, substrate specificities and subcellular localizations.We study how they regulate the pathophysiology of heart failure induced by hypertension, myocardial infarction and metabolic diseases. We use primary cell cultures, transgenic, dietary and surgical mouse models to test Sirtuins for their ability to protect against cardiovascular disease. Our lab techniques range from physiology and biochemistry, to molecular biology and proteomics. Ongoing work in our lab involves studies of the role of Sirtuins in cardiac hypertrophy, fibrosis, mitochondrial dysfunction and muscle degeneration. Our goal is to disclose new biological functions of Sirtuins that can be therapeutically targeted for promoting health-span of heart.
Sirtuins in Cardiovascular diseases–
Our lab studies Sirtuins, a family of histone deacetylases. Mammalian genome encodes seven Sirtuin isoforms (SIRT1-SIRT7), which differ in their structures, substrate specificities and subcellular localizations.We study how they regulate the pathophysiology of heart failure induced by hypertension, myocardial infarction and metabolic diseases. We use primary cell cultures, transgenic, dietary and surgical mouse models to test Sirtuins for their ability to protect against cardiovascular disease. Our lab techniques range from physiology and biochemistry, to molecular biology and proteomics. Ongoing work in our lab involves studies of the role of Sirtuins in cardiac hypertrophy, fibrosis, mitochondrial dysfunction and muscle degeneration. Our goal is to disclose new biological functions of Sirtuins that can be therapeutically targeted for promoting health-span of heart.
研究兴趣
论文共 110 篇作者统计合作学者相似作者
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NUCLEIC ACIDS RESEARCHno. 3 (2024): 1450-1470
ISCIENCEno. 1 (2024): 108601-108601
Microbiology spectrumno. 2 (2023): e0319922-e0319922
MICROBIOLOGY SPECTRUM (2023)
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user-5fe1a78c4c775e6ec07359f9(2023)
FRONTIERS IN MICROBIOLOGY (2023): 1214414-1214414
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMSno. 1 (2023): 194900-194900
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Shweta Kumar, Dimple Nagesh, Venketsubbu Ramasubbu,Arathi Bangalore Prabhashankar,Nagalingam Ravi Sundaresan
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