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个人简介
I’m a neurobiologist with extensive training in studying functional and structural synaptic plasticity, combining electrophysiological, imaging and molecular biological methods in cellular and animal models. After performing my postdoctoral stay, with a Human frontiers fellowship, at Cold Spring Harbor Laboratories, I started my own independent research group in 2011 at the Radboudumc, Nijmegen, the Netherlands, where I’m part of the Donders Institute for Brain, Cognition and Behaviour. I now head the lab of Molecular Neurophysiology consisting of 3 technicians, 13 PhD students and 3 postdocs. The key goal is to reveal novel neurobiological concepts by resolving the genetic and epigenetic networks that are disrupted in neurodevelopmental disorders (NDDs), including intellectual disabilities, autism spectrum disorder and epilepsy. My team uses a multi‐level strategy that combines functional genomics and molecular & cellular neurobiological approaches, such as the generation and characterization of iPSC-derived human neural cells and mouse models. We aim to integrate fundamental neurobiological research with clinical applications and personalized medicine. In particular, our expertise in the generation of patients-derived neural lineages and their neurophysiological analysis at single cell and network level (MEA) is setting the stage in this novel research field. Over the past years, we have established protocols to differentiate iPSCs into a variety of neural lineages (cortical, dopaminergic, serotonergic), with bonafide neurophysiological properties both at the single-cell and network activity level. We have shown that MEAs offer a robust, efficient and physiologically relevant readout to probe for patient-specific neuronal network phenotypes to link genes to NDDs.
研究兴趣
论文共 156 篇作者统计合作学者相似作者
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Imke M.E. Schuurmans, Annika Mordelt,Katrin Linda, Sofia Puvogel, Denise Duineveld,Marina P. Hommersom, Lisa Rahm,Emma Dyke, Gijs-Jan Scholten, Caroline Knorz,Astrid Oudakker,Hans van Bokhoven,
biorxiv(2024)
Zain Awamleh,Sanaa Choufani,Wendy Wu,Dmitrijs Rots,Alexander J. M. Dingemans,Nael Nadif Kasri, Susana Boronat,Salvador Ibañez-Mico, Laura Cuesta Herraiz, Irene Ferrer, Antonio Martínez Carrascal,Luis A. Pérez-Jurado,
European Journal of Human Geneticsno. 3 (2024): 366-366
AUTOPHAGYno. 1 (2024): 15-28
Zain Awamleh,Sanaa Choufani,Wendy Wu,Dmitrijs Rots,Alexander J. M. Dingemans,Nael Nadif Kasri, Susana Boronat,Salvador Ibanez-Mico, Laura Cuesta Herraiz, Irene Ferrer, Antonio Martinez Carrascal,Luis A. Perez-Jurado,
Silvia Radenkovic,Rohit Budhraja, Teun Klein-Gunnewiek,Alexia Tyler King,Tarun N. Bhatia,Anna N. Ligezka,Karen Driesen, Rameen Shah,Bart Ghesquiere, Akhilesh Pandey,Nael Nadif Kasri,Steven A. Sloan,
CELL REPORTSno. 3 (2024): 113883-113883
Marina P. Hommersom,Nina Doorn, Sofía Puvogel,Elly I. Lewerissa, Annika Mordelt,Ummi Ciptasari, Franziska Kampshoff, Lieke Dillen,Ellen van Beusekom,Astrid Oudakker,Naoki Kogo,Monica Frega,
biorxiv(2024)
Molecular psychiatryno. 4 (2023): 1400-1401
Epilepsia (2023)
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