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个人简介
I received my PhD in Molecular Biology in the laboratory of Pr. Nicolas Levy at the Marseille Medical School, France where he worked on the development of new diagnosis tools for neuromuscular diseases, the discovery of the Minidysferlin and its use for gene transfer, and investigated the use of exon-skipping for dysferlinopathies. In 2011, I joined the team of Pr. Kevin Flanigan at Nationwidechildrens Hospital, Columbus, OH, USA as a postdoctoral scientist, where I'm developing therapeutic strategies for patient with 5' mutation in DMD gene. Our lab focuses on neuromuscular disorders such as Duchenne Muscular dystrophy, which is a devastating disease leading to death of patients at 20-30 years of age. I become assistant Professor in 2016 and our lab has developed an expertise in translational research, an emerging field which can be summarized as understanding the cause of a disease and learning from it in order to develop innovative therapeutic strategies. We are fully committed to continuing to integrate basic science and gene therapy skills in order to advance understanding and treatment of the muscular dystrophies. Our long-term projects focus on RNA and DNA editing and gene transfer as therapies for neuromuscular disorders, but they will also include more fundamental research on muscle function. In particular, our lab uses the newest technologies, such as virus-mediated exon-skipping and the CRISPR/Cas9 genome editing tool.
研究兴趣
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Frontiers in Cellular Neuroscience (2023): 1248922-1248922
Molecular therapy : the journal of the American Society of Gene Therapyno. 9 (2023): 2767-2782
Frontiers in cell and developmental biology (2023): 1181040
MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT (2023): 101144-101144
MOLECULAR THERAPYno. 4 (2023): 396-396
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J. Lay, E. Frair, A. Bradley,T. Vetter, N. Rohan, C. Bellinger,M. Waldrop,N. Wein,L. Gushchina,K. Flanigan
MOLECULAR THERAPYno. 4 (2023): 332-333
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Liubov V. Gushchina, A. Bradley,Tatyana A. Vetter, Jacob W. Lay, N. Rohan, E. Frair,Nicolas Wein,Kevin M. Flanigan
Molecular Therapy - Methods & Clinical Developmentpp.101144-101144, (2023)
Liubov V. Gushchina,Tatyana A. Vetter,Emma C. Frair,Adrienne J. Bradley,Kelly M. Grounds, Jacob W. Lay,Nianyuan Huang,Aisha Suhaiba,Frederick J. Schnell,Gunnar Hanson, Tabatha R. Simmons,Nicolas Wein,
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