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个人简介
Nelson Ruiz-Opazo, PhD, is a Professor of Medicine at Boston University School of Medicine, Whitaker Cardiovascular Institute. He has a Master’s Degree in Molecular Biology from Austral University, Valdivia, Chile and a PhD in Cell Biology from the Albert Einstein College of Medicine, a post-doctoral fellowship in Molecular Cardiology at Boston Children’s Hospital, Harvard Medical School and Instructor of Medicine at Harvard Medical School of Medicine.
His research interests span the molecular genetics of hypertension and target organ complications, identification of novel genes and therapeutic paradigms in cancer with a focus on cancer stem cell pathological extended survival and pathological angiogenesis, in stroke with a focus on dysregulated neutrophils’ extended survival, and in ARDS +/- COVID19 with a focus on neutrophil-monocyte reciprocal co-activation in the propagation of hyperinflammation-mediated multi-organ tissue injury.
His research expertise spans molecular and cell biology analysis of cancer stem cells (CSC), CSC-derived tumor cell phenotypes, xenograft modeling using CSCs, and conducting survival analysis to test efficacy and safety of novel targeted therapies in cancer focusing on high unmet need cancers – pancreatic peritoneal carcinomatosis, glioblastoma. In molecular genetics research, expertise spans GWAS analysis of F2-genetic hypertensive cohorts and associated candidate genes, GWAS analysis of genetic F2 intercross linkage studies of Learning and Memory and associated candidate genes, hypertension genetic studies in isolated human populations, transgenic rat modeling. In ARDS, expertise spans translational approaches via ex vivo analysis of clinical samples relevant to the elucidation of the pathogenic microenvironment in which novel therapies will need to demonstrate efficacy and safety pertinent to future clinical trials.
研究兴趣
论文共 143 篇作者统计合作学者相似作者
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Research squareno. 1 (2023): 12-12
Ragnhild D Whitaker, Julius L Decano, Catherine Gormley, Carl A Beigie, Cari Meisel, Glaiza A Tan, Ann-Marie Moran, Nicholas J Giordano,Yoonjee Park, Peng Huang, Sean Andersson, Donald Gantz,
Theranosticsno. 18 (2022): 7646-7667
Ragnhild D. Whitaker, Julius L. Decano, Catherine Gormley, Carl A. Beigie, Cari Meisel, Glaiza A. Tan, Ann-Marie Moran, Nicholas J. Giordano,Yoonjee Park, Peng Huang, Sean Andersson, Donald Gantz,
THERANOSTICSno. 18 (2022): 7646-7667
Victoria L. M. Herrera,Allan J. Walkey,Mai Q. Nguyen, Christopher M. Gromisch,Julie Z. Mosaddhegi,Matthew S. Gromisch, Bakr Jundi,Soeren Lukassen,Saskia Carstensen, Ridiane Denis,Anna C. Belkina,Rebecca M. Baron,
SCIENTIFIC REPORTSno. 1 (2022)
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