基本信息
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Bio
Most important awards, prizes and academies
Awards: Academy of Sciences, France; Royal Academy of Belgium; Kyoto Prize in Advanced Technology, Japan; Jeantet Prize in Medicine; Grand Prix de la Fondation pour la Recherche Médicale; Ross Harrison Prize of Columbia University, New York; The Pearl Meister Greengard Prize, The Rockefeller University, New York; The Conklin Award of the American Society for Developmental Biology, San Francisco; Grand Officier dans l'Ordre National du Mérite; Commandeur dans l'Ordre de la Légion d'honneur; Grand Croix dans l'Ordre National du Mérite; Commandeur dans l'Ordre des Palmes académiques. Academies: Académie des sciences, France; American Academy of Arts and Sciences; Academia Europaea; Pontifical Academy of Sciences; National Academy of Sciences, USA; Royal Society, UK; Royal Academy of Medicine of Spain; Royal Academy of Belgium; Academy of Athens.
Summary of scientific research
My work deals with the development of the nervous and the hemopoietic and angiogenic systems in the vertebrate embryo. I devised a cell marking technique which enables the migration and fate of cells to be followed within the embryo during the entire developmental period. With my colleagues, we have particularly studied the fate of the neural crest, an embryonic structure composed of pluripotent stem cells. Neural crest cells undergo extensive migrations within the embryo and differentiate into a large variety of cell types. The neural crest plays a crucial role in the construction of the vertebrate head and of the peripheral nervous system. It also yields pigment and endocrine cells. We established the embryonic origin of the hemopoietic stem cells and how the development of the immune system proceeds in the embryo and early post-natal life. We demonstrated that immune tolerance to self involves, in addition to the elimination of self reactive T cells in the thymus, an active mechanism which consists in the production in the thymic environment of regulatory cells that suppress the activity of the effector T cells that have escaped thymic elimination.
Research Interests
Papers共 40 篇Author StatisticsCo-AuthorSimilar Experts
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Author Statistics
#Papers: 40
#Citation: 3740
H-Index: 27
G-Index: 36
Sociability: 4
Diversity: 3
Activity: 0
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