基本信息
浏览量:1
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
The adult brain consists of a large number of neurons and glial cells, most of which are generated during embryogenesis from neuroepithelial stem cells. Neural stem cells are highly specialised with respect to the neurons they generate, thus creating the extensive neuronal diversity that exists in the adult brain.
We focus on cortical inhibitory interneurons, a heterogeneous population of neurons implicated in neurodevelopmental disorders such as autism and schizophrenia. Using molecular genetic tools in model organisms, we have been mapping out their stem cell origins. Using loss- and gain-of-function approaches in vivo, we are examining the role of signalling pathways and other mechanisms involved in interneuron specification. Interneurons in the adult cortex connect to their cortical targets in a highly specialized manner. We are investigating molecular mechanisms the mediate synaptic partner selection. Our aim is to gain insight into the role of subtype-specific wiring of interneurons in functional neural assemblies.
Another area of high complexity in terms of neuronal composition is the septum. Located at a nodal point in the forebrain, the septum forms an integral part of the limbic system that regulates emotion and memory. We are examining the embryonic origin and specification of septal neurons. Using in vivo approaches we are looking into the role of different neuronal populations in septal circuits and how perturbations of the system can affect behaviour.
We focus on cortical inhibitory interneurons, a heterogeneous population of neurons implicated in neurodevelopmental disorders such as autism and schizophrenia. Using molecular genetic tools in model organisms, we have been mapping out their stem cell origins. Using loss- and gain-of-function approaches in vivo, we are examining the role of signalling pathways and other mechanisms involved in interneuron specification. Interneurons in the adult cortex connect to their cortical targets in a highly specialized manner. We are investigating molecular mechanisms the mediate synaptic partner selection. Our aim is to gain insight into the role of subtype-specific wiring of interneurons in functional neural assemblies.
Another area of high complexity in terms of neuronal composition is the septum. Located at a nodal point in the forebrain, the septum forms an integral part of the limbic system that regulates emotion and memory. We are examining the embryonic origin and specification of septal neurons. Using in vivo approaches we are looking into the role of different neuronal populations in septal circuits and how perturbations of the system can affect behaviour.
研究兴趣
论文共 107 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Sarah Foerster,Elisa M Floriddia,David van Bruggen,Petra Kukanja, Bastien Hervé, Shangli Cheng,Eosu Kim,Benjamin U Phillips,Christopher J Heath,Richa B Tripathi,Cody Call,Theresa Bartels,
Nature neurosciencepp.1-10, (2024)
Current opinion in neurobiology (2023): 102703-102703
Lorenza Magno,Zeinab Asgarian,Valentina Pendolino,Theodora Velona, Albert Mackintosh,Flora Lee,Agata Stryjewska,Celine Zimmer,François Guillemot, Mark Farrant,Beverley Clark,Nicoletta Kessaris
引用0浏览0引用
0
0
Stem cell reportsno. 5 (2019): 793-802
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn