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个人简介
My group and collaborators seek to reach a neural circuit-level understanding of human spatial and episodic memory, focusing on the role of the hippocampus. We design and perform single-unit recording, EEG, fMRI, MEG, neuropsychological and behavioural experiments in humans and rodents, and use computational modeling to integrate the results. The group encourages interaction between modeling and experiment by being directly involved in both. We discovered how environmental cues determine the firing of hippocampal “place cells” which represent a rat’s current location via the firing of putative “boundary vector cells” (BVC) (which have now been found), enabling prediction of place cell firing in new environments. We also demonstrated the presence of attractor dynamics, long-term experience-dependent plasticity and temporal coding within hippocampal neuronal representations. In humans we have pioneered the use of virtual reality (VR) to investigate the neural mechanisms of spatial memory, identifying the specific contributions of hippocampal and striatal systems to spatial navigation, and the learning rules employed by each. Computational models include the firing of entorhinal cortical grid cells as the interference of theta-frequency membrane potential oscillations, and human memory for spatial context as the interaction between neural firing patterns in medial temporal and parietal areas. These models can explain the patterns of fMRI activation in remembering or imagining spatial scenes, and can predict the search patterns of humans within VR environments.
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Nature Communicationsno. 1 (2024): 1-17
Mattias Horan, Daniel Regester,Cristina Mazuski, Thomas Jahans-Price, Shanice Bailey, Emmett Thompson, Zuzanna Slonina, Viktor Plattner, Elena Menichini, Irmak Toksöz, Sandra Romero Pinto, Mark Burrell,
crossref(2024)
Current Biologyno. 10 (2024): 2256-2264.e3
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Neural networks : the official journal of the International Neural Network Society (2023): 473-488
Psychological reviewno. 2 (2023): 578-597
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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