基本信息
views: 167
Career Trajectory
Bio
HONORS:
Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2008)
Ta-Yu Wu Memorial Award, National Science Council, Taiwan (2008)
Dr. Ta-Cheng Tung Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan (2009)
First prize of Distinguished Thesis, Taipei Veterans General Hospital (2009, 2011)
Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan (2011)
Award for Junior Research Investigators, Academia Sinica (2011)
RESEARCH INTERESTS:
Epithelial-mesenchymal transition (EMT) is one of the major mechanisms of cancer metastasis. However, the pleiotropic effects of EMT regulators in additional to the promotion of cellular migration have been investigated limitedly. We recently discover several novel functions of the EMT regulators during head and neck cancer progression. First, we confirm the direct regulation of the stemness-related gene BMI1 by the EMT regulator Twist1. Twist1 and BMI1 are mutually essential in promoting EMT and tumor-initiating capability. Second, we identify the mechanism of Twist1-induced motility through repressing microRNA let-7i and activating RAC1. Third, we show the induction of chromosomal instability by BMI1 through upregulating Aurora A expression. Fourth, we find a pathway of Snail-induced cisplatin resistance through induction of ERCC1 expression. In the future, we will keep focusing on the pleiotropic effects of EMT regulators during cancer metastasis and confirm their clinical significance.
Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2008)
Ta-Yu Wu Memorial Award, National Science Council, Taiwan (2008)
Dr. Ta-Cheng Tung Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan (2009)
First prize of Distinguished Thesis, Taipei Veterans General Hospital (2009, 2011)
Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan (2011)
Award for Junior Research Investigators, Academia Sinica (2011)
RESEARCH INTERESTS:
Epithelial-mesenchymal transition (EMT) is one of the major mechanisms of cancer metastasis. However, the pleiotropic effects of EMT regulators in additional to the promotion of cellular migration have been investigated limitedly. We recently discover several novel functions of the EMT regulators during head and neck cancer progression. First, we confirm the direct regulation of the stemness-related gene BMI1 by the EMT regulator Twist1. Twist1 and BMI1 are mutually essential in promoting EMT and tumor-initiating capability. Second, we identify the mechanism of Twist1-induced motility through repressing microRNA let-7i and activating RAC1. Third, we show the induction of chromosomal instability by BMI1 through upregulating Aurora A expression. Fourth, we find a pathway of Snail-induced cisplatin resistance through induction of ERCC1 expression. In the future, we will keep focusing on the pleiotropic effects of EMT regulators during cancer metastasis and confirm their clinical significance.
Research Interests
Papers共 313 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jameel Muzaffar,Kedar Kirtane, Rebecca Redman,Muh-Hwa Yang,Tae Min Kim,Stephen Liu,Ryan Lynch,Julie Brahmer, Patricia LoRusso,Brian Henick,Sung-bae Kim,Yin-Hsun Feng,
Cancer Researchno. 7_Supplement (2024)
Hung-Hsi Chen,Hsin-I Yu, Jason Jie-Sheng Chang,Chia-Wei Li,Muh-Hwa Yang,Mien-Chie Hung,Woan-Yuh Tarn
Cell Reportsno. 3 (2024): 113937-113937
CANCER SCIENCEno. 1 (2024): 270-282
BMC Cancerno. 1 (2024): 1-11
npj Virusesno. 1 (2024): 1-10
Ming-Yu Chou, Wen-Chi Wu,Pen-Yuan Chu,Shyh-Kuan Tai,Peter Mu-Hsin Chang,Tsung-Lun Lee,Tien-Hua Chen,Muh-Hwa Yang
In vivo (Athens, Greece)no. 4 (2024): 1891-1899
Cancer Researchno. 6_Supplement (2024): 7612-7612
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn