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Dr. Salmon’s research interests include investigation of epigenetic mechanisms that alter aortic aneurysm growth and that affect smooth muscle, endothelial or adventitial cell marker expression in aortic aneurysms. She has investigated the role of Krüppel-like factor 4 in smooth muscle cells in aortic aneurysms and found that Krüppel-like factor 4 was also important for the transcriptional regulation of smooth muscle cell marker genes in aortic aneurysms (Circulation 2013). She is also interested in the role of zinc-finger proteins in transcriptional regulation of smooth muscle cells in aortic aneurysms. As part of these investigations, she has become interested in using lineage tracking systems to follow the localization and expression of various resident cell populations during aneurysm progression. Morgan has also assisted in the investigation of the IL-1 signaling pathway in early and late stage aortic aneurysms. Elimination of IL-1β or IL-1R1 was found to significantly attenuate small abdominal and thoracic aortic aneurysms (ATVB 2012, Circulation 2015). She is currently investigating effects of Anakinra treatment in a newly developed chronic abdominal aortic aneurysm models to determine if Anakinra can inhibit large advanced aneurysms as seen in humans. She is also working on studies looking at the conditional elimination of IL-1R1 in tissues important to aneurysm formation. Dr. Salmon has an established mentoring track record with mentees winning awards at STS, AHA, and ACS.
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BIOMEDICINESno. 1 (2024): 3-1233
The Journal of Thoracic and Cardiovascular Surgery (2023)
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Journal of cellular immunologyno. 2 (2023): 22-31
The Journal of thoracic and cardiovascular surgeryno. 5 (2023): e146-e158
Nisakorn Yodsanit,Takuro Shirasu,Yitao Huang,Li Yin, Zain Husain Islam,Alexander Christopher Gregg,Alessandra Marie Riccio,Runze Tang, Eric William Kent,Yuyuan Wang,Ruosen Xie,Yi Zhao,
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