基本信息
浏览量:43
职业迁徙
个人简介
The Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities.
To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome.
By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease.
To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome.
By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease.
研究兴趣
论文共 52 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Magdalena P. Crossley,Chenlin Song,Michael J. Bocek, Jun-Hyuk Choi, Joseph N. Kousouros,Ataya Sathirachinda,Cindy Lin,Joshua R. Brickner,Gongshi Bai,Hannes Lans,Wim Vermeulen,Monther Abu-Remaileh,
Natureno. 7998 (2024): E6-E6
Kwamina Nyame, Andy Hims, Aya Aburous,Nouf N. Laqtom, Wentao Dong, Uche N. Medoh,Julia C. Heiby, Jian Xiong, Alessandro Ori,Monther Abu-Remaileh
Michael S. Haney,Róbert Pálovics, Christy Nicole Munson, Chris Long,Patrik K. Johansson, Oscar Yip,Wentao Dong,Eshaan Rawat, Elizabeth West,Johannes C. M. Schlachetzki, Andy Tsai, Ian Hunter Guldner,
Naturepp.1-8, (2024)
Annual review of biochemistry (2024)
Yong Yu,Shihong M. Gao, Youchen Guan,Pei-Wen Hu,Qinghao Zhang, Jiaming Liu, Bentian Jing,Qian Zhao,David M. Sabatini,Monther Abu-Remaileh,Sung Yun Jung,Meng C. Wang
ELIFE (2024)
Monther Abu-Remaileh,Sebastian Bender,Günter Raddatz, Ihab Ansari, Daphne Cohen,Julian Gutekunst,Tanja Musch,Heinz Linhart,Achim Breiling,Eli Pikarsky,Yehudit Bergman,Frank Lyko
crossref(2023)
Michael S Haney,Róbert Pálovics, Christy Nicole Munson, Chris Long,Patrik Johansson, Oscar Yip,Wentao Dong,Eshaan Rawat, Elizabeth West,Johannes Cm Schlachetzki,Andy Tsai,Ian Hunter Guldner,
bioRxiv : the preprint server for biology (2023)
Monther Abu-Remaileh,Sebastian Bender,Günter Raddatz, Ihab Ansari, Daphne Cohen,Julian Gutekunst,Tanja Musch,Heinz Linhart,Achim Breiling,Eli Pikarsky,Yehudit Bergman,Frank Lyko
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn