基本信息
views: 17
Career Trajectory
Bio
Dr Shamji has a specific interest in respiratory allergies, especially how disease-modifying treatments such as allergen immunotherapy, novel biologics and novel immunomodulators (Toll-Like Receptor (TLR) 7 and Surfactant protein (SP)-D) affect immunologic (T, B cell and immunoglobulins) responses leading to induction of immune tolerance, as well as the investigation of novel surrogate/predictive biomarkers of clinical outcome following successful immunotherapy.
He is actively involved in evaluating novel approaches of allergen immunotherapy using modified hypoallergic form of allergen protein, subcutaneous immunotherapy in combination with novel adjuvants, sublingual immunotherapy, peptide immunotherapy, biologics plus allergen of interest strategies to improve safety, efficacy and induce immune tolerance to sensitising allergen.
This involves:
1) Designing human pre-clinical laboratory mechanistic studies to test allergenicity and immunogenicity of novel modified/hypoallergenic allergen and T/B cell peptides
2) Investigating immunologic mechanisms of immunotherapy in the context of clinical trials (in collaboration with Professor Stephen Durham, within Allergy and Clinical Immunology (ACI) or contract research organisation (CRO), pharmaceutical or biotech companies).
In collaboration with Professor Adnan Custovic and Dr Paul Turner, Dr Shamji is investigating mechanisms of desensitisation and tolerance induction following oral peanut/milk immunotherapy by translating his work from respiratory disease human models.
Dr Shamji’s research has resulted in multiple peer-reviewed publications in high impact journals in the field of Allergy. His publications in the Journal of Allergy and Clinical Immunology have been selected as editor’s choice. He has written two book chapters on mechanisms and biomarkers of AIT (Allergens and Allergen Immunotherapy: Subcutaneous, Sublingual, and Oral, Fifth Edition, CRC press).
He is actively involved in evaluating novel approaches of allergen immunotherapy using modified hypoallergic form of allergen protein, subcutaneous immunotherapy in combination with novel adjuvants, sublingual immunotherapy, peptide immunotherapy, biologics plus allergen of interest strategies to improve safety, efficacy and induce immune tolerance to sensitising allergen.
This involves:
1) Designing human pre-clinical laboratory mechanistic studies to test allergenicity and immunogenicity of novel modified/hypoallergenic allergen and T/B cell peptides
2) Investigating immunologic mechanisms of immunotherapy in the context of clinical trials (in collaboration with Professor Stephen Durham, within Allergy and Clinical Immunology (ACI) or contract research organisation (CRO), pharmaceutical or biotech companies).
In collaboration with Professor Adnan Custovic and Dr Paul Turner, Dr Shamji is investigating mechanisms of desensitisation and tolerance induction following oral peanut/milk immunotherapy by translating his work from respiratory disease human models.
Dr Shamji’s research has resulted in multiple peer-reviewed publications in high impact journals in the field of Allergy. His publications in the Journal of Allergy and Clinical Immunology have been selected as editor’s choice. He has written two book chapters on mechanisms and biomarkers of AIT (Allergens and Allergen Immunotherapy: Subcutaneous, Sublingual, and Oral, Fifth Edition, CRC press).
Research Interests
Papers共 390 篇Author StatisticsCo-AuthorSimilar Experts
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Janice A. Layhadi, Anastasia Lalioti,Elizabeth Palmer,Menno C. van Zelm,Erik Wambre,Mohamed H. Shamji
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICEno. 1 (2024): 59-66
Ludger Klimek,Adam Chaker,Valérie Hox,Stefano Del Giacco,Philippe Gevaert,Mohamed Shamji,Sanna Toppila Salmi,Patrizia Bonadonna,Jolanta Walusiak-Skorupa, André Morreira,Oscar Palomares,Oliver Pfaar,
Allergy (2024)
Mihir M Shah,Janice A Layhadi,Dennis E Hourcade, William T Fulton,Tiak Ju Tan, Diane Dunham, Iris Chang, Monica S Vel, Andrea Fernandes, Alexandra S Lee, James Liu,Prabhu S Arunachalam,
Allergy (2024)
CLINICAL AND EXPERIMENTAL ALLERGYno. 2 (2024): 130-142
ALLERGY (2024)
P. J. de Kam,S. Zielen, J. A. Bernstein,U. Berger,M. Berger, M. Cuevas,D. Cypcar, A. Fuhr-Horst, W. A. Greisner,M. Jandl,S. Lassmann,M. Worm,
ALLERGYno. 6 (2024): 1637-1638
Annals of Allergy, Asthma & Immunology (2024)
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunologyno. 5 (2024): 308-310
ALLERGY (2024)
ALLERGY (2024)
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Author Statistics
#Papers: 397
#Citation: 8925
H-Index: 52
G-Index: 90
Sociability: 8
Diversity: 0
Activity: 7
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