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The Moellering Laboratory of Chemical Biology is focused on the development of novel chemical tools and technology platforms to map and manipulate protein structure, function and signaling in complex biological environments. To do so, we have developed and applied an array of novel proteomic technology platforms, chemical probes and therapeutic modalities. A unifying biological theme of our research is understanding how the dynamic chemical and genetic environment of cells is sensed and converted into integrated signaling responses that control cellular homeostatic mechanisms, as well as how altered protein function and signaling is dysregulated in disease. Overall, our research interests are centered on the science of probing and perturbing the proteome in biological systems rather than one specific technology platform or disease context. In this context we are interested in understanding fundamental phenomena in proteome regulation, signaling, methods for quantitative measurement of proteome activity and topology, as well as creating new chemical probes and prototype therapeutics. We believe these concerted activities are capable of spanning basic and translational science, with the aim of making discoveries and methods available for the broader scientific community.
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论文共 56 篇作者统计合作学者相似作者
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Thomas E. Speltz, Zeyu Qiao,Colin S. Swenson, Xianghang Shangguan,John S. Coukos,Christopher W. Lee,Deborah M. Thomas, Jesse Santana,Sean W. Fanning,Geoffrey L. Greene,Raymond E. Moellering
Nature Methodsno. 7 (2021): 763-767
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