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个人简介
Dr. Mirjam H.M. Heemskerk, Ph.D., is Associate Professor and Head of the Laboratory of Experimental Hematology at the Department of Hematology, Leiden University Medical Center, and was a postdoctoral fellow from 1994 till 1998 at the Netherlands Cancer Institute, Amsterdam. In 1999 she received a Gisela Their fellowship and started her own research group in 2001 at the Department of Hematology, LUMC, Leiden. Identification of high affinity TCRs, useful for TCR gene therapeutic strategies in both hematological malignancies and solid tumors, is one of the pillars of my research.
In addition, biology of TCRs, and optimizing TCR gene transfer is studied intensively in my group. We recently demonstrated that creation of a non-competitive TCR environment following simultaneous knock out of both endogenous TCRαβ chains by CRISPR/Cas9 genomic editing resulted in an improved cellular therapeutic with increased performance in preclinical murine models for multiple myeloma. Since TCRs intrinsically exhibit cross-reactive potential, different methods to analyse safety and specificity of TCRs have been develop in my laboratory. Part of tumor-specific-TCRs are currently tested in clinical TCR gene therapy studies. In 2013 the first clinical TCR gene therapy study in the Netherlands for treatment of high risk leukemia using the HA-1H-TCR (N2021789) was started in LUMC. A new Phase I/II dose-escalation HA-1H-TCR clinical trial has started in July 2020.
研究兴趣
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NPJ vaccinesno. 1 (2024): 1-1
CANCER GENE THERAPYno. 1 (2024): 58-68
Roderick C. Slieker, Daniel O. Warmerdam,Maarten H. Vermeer,Remco van Doorn,Mirjam H. M. Heemskerk,Ferenc A. Scheeren
SCIENTIFIC REPORTSno. 1 (2024): 7966-7966
Geert V.T. Roozen, Manon L.M. Prins,Corine Prins,Jacqueline J. Janse, Heidi L.M. de Gruyter,Cilia R. Pothast,Wesley Huisman,Jan Pieter R. Koopman,Olivia A.C. Lamers,Marjan Kuijer,Sebenzile K. Myeni,Rob S. van Binnendijk,
Clinical Microbiology and Infectionno. 7 (2024): 930-936
Linda Voogd, Anne M. H. F. Drittij, Calinda K. E. Dingenouts,Kees L. M. C. Franken,Vincent van Unen,Krista E. van Meijgaarden,Paula Ruibal,Renate S. Hagedoorn,Judith A. Leitner,Peter Steinberger,Mirjam H. M. Heemskerk,Mark M. Davis,
ISCIENCEno. 3 (2024): 109233-109233
Jordi Rovira,Carolt Arana, Ainhoa Garcia-Busquets,Ilse Gille,Luís F. Quintana,Mirjam H.M. Heemskerk,Sebastiaan Heidt,Eduard Palou,Fritz Diekmann
Kidney Internationalno. 6 (2024): 1320-1320
Tom A.W. Schoufour, Anneloes van der Plas - van Duijn, Ian Derksen, Marije Melgers, Jacqueline M.F. van Veenendaal, Claire Lensen,Mirjam H.M. Heemskerk,Jacques Neefjes,Ruud H.M. Wijdeven,Ferenc A. Scheeren
iScienceno. 6 (2024): 110120-110120
W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens,M. H. M. Heemskerk
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