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Bio
I am a Structural Biologist with extensive experience in the field of macromolecular crystallography, cryo-EM/cryo-ET, Biochemistry, and Biophysical Methods. Currently, I am working as a Research Assistant Professor at the Vanderbilt University, Nashville, TN, USA. Prior to this, I worked at the Institute for Molecular Biosciences (IMB), University of Queensland, Australia as a Post-Doctoral Research Officer from May 2016 to December 2018. I have completed my Ph.D. (year 2016) in the field of Structural Biology and Biochemistry at the prestigious Indian Institute of Science Education and Research (IISER) Bhopal, India, under the supervision of A/Prof. Sunando Datta.
My long-standing interest has been to understand how cells work, and the techniques used to visualize the complex interaction mechanisms of the structures within the cell. Seeing the structure of a protein at the atomic level as a Ph.D. scholar set off my career in Structural Biology and Biophysics. Post-Doctorate work at University of Queensland, Australia and Vanderbilt University, USA, steered me towards ‘membrane trafficking’, the term used to describe how proteins are moved from one part of a cell to another, or indeed between cells, via a complex system of membranes. As a Postdoctoral researcher, I have strategically used this opportunity to gain experience in membrane protein biology and biophysical and structural techniques for protein characterization and have developed into an experienced molecular protein biologist.
During my first Post-Doctoral training (from 2016-2018) at Prof. Brett Collins lab, my research was focused to understand the molecular basis of membrane trafficking mediated by the Phox Homology (PX) domains. I systematically screened all human PX domains for their phospholipid preferences. My comprehensive study on PX domain structures revealed two distinct binding sites that explain their lipid specificities, providing a basis for defining and predicting the functional membrane interactions of the entire PX domain protein family.
In early 2019, I was invited to join the lab of A/Prof. Lauren Parker Jackson, renowned for her pioneering efforts to understand the Retromer coat assembly and regulation on endosomes, as a postdoctoral scientist at the Vanderbilt University, Nashville, Tennessee, USA. Currently, I am trying to understand the molecular mechanisms by which the Retromer complex (VPS26/VPS35/VPS29 subunits) interacts with SNX27 using single particle cryo-EM and cryo-ET. Retromer plays a fundamental role in nutrition. Although SNX27 appears to facilitate cargo specificity of Retromer, regulatory mechanisms for SNX27/Retromer assembly during receptor recycling remain elusive. I aim to identify novel regulators associated with SNX27/Retromer assembly and investigate their role in receptor recycling to the plasma membrane.
My doctoral dissertation was focused on biophysical and structural studies of RabX3, a unique and catalytically inefficient tandem Rab GTPase from Entamoeba histolytica. I identified how the conventional GTP/GDP cycle is regulated in EhRabX3 and what is the molecular basis of low catalytic efficiency of this atypical Rab protein.
My future goal is to develop an independent research program aimed at understanding the protein-protein and protein-small molecule interactions with the help of protein biochemistry, biophysics, X-ray crystallography and cryo-EM/cryo-ET. We all have evolved highly sophisticated protein machineries to control the flow of trans-membrane molecules and lipids between different organelles. Any disruption of these processes are linked to numerous diseases including neurodegenerative disorders and cancer. Using cutting-edge structural, molecular and cellular approaches I aim to determine how these trafficking machineries are assembled and regulated at the molecular level. My future goal is to provide a molecular foundation for identifying target sites and rational design for developing potential therapeutics for various human disease.
Research Interests
Papers共 30 篇Author StatisticsCo-AuthorSimilar Experts
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Jing Zhi Anson Tan,Se Eun Jang, Ana Batallas-Borja,Nishita Bhembre,Mintu Chandra,Lingrui Zhang, Huimin Guo,Mitchell T. Ringuet,Jocelyn Widagdo,Brett M. Collins,Victor Anggono
CELL REPORTSno. 12 (2023): 113460-113460
Frontiers in cell and developmental biology (2021): 642378-642378
Advances in biological regulation (2021): 100781-100781
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