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As a future biomedical scientist, I understand it is critical to have a comprehensive understanding not only in focused research fields but also be capable of analyzing and solving practical problems. My current research focuses on study of islets tissue, inflammation, cell preservation, regeneration and transplantation. I have worked on the lacritin projects and it was a great learning process and I have learned so much in translating conceptual ideas to practically viable procedures. Type 1 diabetes is an autoimmune disease characterized by the selective destruction of insulin-producing β-cells that results ultimately in the complete loss of insulin secretion and glycometabolic regulation and rescuing β-cells could benefit millions of individuals. We recently made the surprising discovery that β-cells from freshly isolated mouse and human islets are fully or partially restored with synthetic peptide 'N-94', has been detected in plasma as three C-terminal peptides inclusive in large part of the N-94 sequence KQFIENGSEFAQKLLKKFSLLKPWA. N-94 and N-94/C-6, but not 'C-95' lacking the N-94 domain promote mouse and human islet viability and enhance insulin secretion in a dose dependent manner, in keeping with islet expression of lacritin’s mitogenic and prosurvival pathways and highly specific co-receptor/receptor complex. Now, fourteen untested N-94/C-6 analogs and other analogs have been developed and synthesized. Leveraging E-cell-specific mitogenic properties of N-94, N-94/C-6 or analogs to replenish functional E-cell mass, as well as utilizing their prosurvival and anti-inflammatory properties to protect E-cells in individuals at high risk of developing type 1 diabetes or with new onset diabetes, is an innovative therapeutic intervention with significant benefits.
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TRANSPLANTATIONno. 9 (2022): S738-S738
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OBM Transplantationno. 4 (2018): 1-1
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