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RESEARCH INTERESTS
We are interested in how the brain perceives sensory information and responds appropriately using the mouse olfactory system as a model. Rodents primarily use olfactory cues to guide their behaviors (e.g., locating food, communicating with conspecifics, and avoiding danger). Odor detection relies on a large family (~1200 in mice) of G-protein coupled odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) in the nose. OSNs transmits sensory information to the olfactory bulb (the first relay station in the brain), which projects to several olfactory cortical and subcortical regions. Some OSNs serve dual functions as odor detectors and mechanical sensors, thus the olfactory system carries both the odor information and nasal breathing signal into the brain. Our current investigation focuses on how the olfactory system interacts with non-olfactory regions (e.g., the prefrontal cortex and striatum) to influence the brain activity and behavioral output. Since olfactory dysfunction is manifested in neuropsychiatric and neurodegenerative disorders, we are also interested in analyzing the olfactory system and related circuits in diseased states.
RESEARCH TECHNIQUES
optogenetics, ex vivo and in vivo electrophysiology, fiber photometry, neural circuit tracing, mouse behavior, CRISPR-cas9 gene editing, immunohistochemistry, molecular biology
We are interested in how the brain perceives sensory information and responds appropriately using the mouse olfactory system as a model. Rodents primarily use olfactory cues to guide their behaviors (e.g., locating food, communicating with conspecifics, and avoiding danger). Odor detection relies on a large family (~1200 in mice) of G-protein coupled odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) in the nose. OSNs transmits sensory information to the olfactory bulb (the first relay station in the brain), which projects to several olfactory cortical and subcortical regions. Some OSNs serve dual functions as odor detectors and mechanical sensors, thus the olfactory system carries both the odor information and nasal breathing signal into the brain. Our current investigation focuses on how the olfactory system interacts with non-olfactory regions (e.g., the prefrontal cortex and striatum) to influence the brain activity and behavioral output. Since olfactory dysfunction is manifested in neuropsychiatric and neurodegenerative disorders, we are also interested in analyzing the olfactory system and related circuits in diseased states.
RESEARCH TECHNIQUES
optogenetics, ex vivo and in vivo electrophysiology, fiber photometry, neural circuit tracing, mouse behavior, CRISPR-cas9 gene editing, immunohistochemistry, molecular biology
研究兴趣
论文共 118 篇作者统计合作学者相似作者
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Mayank Gautam,Akihiro Yamada,Ayaka I Yamada,Qinxue Wu, Kim Kridsada,Jennifer Ling,Huasheng Yu, Peter Dong,Minghong Ma,Jianguo Gu,Wenqin Luo
Nature communicationsno. 1 (2024): 2911-2911
Natalie L Johnson, Anamaria Cotelo-Larrea,Lucas A Stetzik, Umit M Akkaya,Adrienn G Varga,Minghong Ma,Daniel W Wesson
biorxiv(2024)
Kun Yang,Yuto Hasegawa,Janardhan P. Bhattarai,Jun Hua, Milan Dower,Semra Etyemez,Neal Prasad, Lauren Duvall,Adrian Paez,Amy Smith, Yingqi Wang, Yun-Feng Zhang,
Molecular Psychiatrypp.1-12, (2024)
Mayank Gautam,Akihiro Yamada,Ayaka I. Yamada,Qinxue Wu, Kim Kridsada,Jennifer Ling,Huasheng Yu, Peter Dong,Minghong Ma,Jianguo Gu,Wenqin Luo
NATURE COMMUNICATIONSno. 1 (2024)
Yusha Sun, Xin Wang,Daniel Y Zhang,Zhijian Zhang,Janardhan P Bhattarai, Yingqi Wang, Weifan Dong,Feng Zhang, Kristen H Park, Jamie Galanaugh,Abhijeet Sambangi,Qian Yang,
bioRxiv : the preprint server for biology (2024)
Mayank Gautam,Akihiro Yamada,Ayaka I Yamada,Qinxue Wu, Kim Kridsada,Jennifer Ling,Huasheng Yu, Peter Dong,Minghong Ma,Jianguo Gu,Wenqin Luo
Nature communicationsno. 1 (2024): 3694-3694
Methods in molecular biology (Clifton, N.J.) (2023): 49-60
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Friederike D. Seifert, Marco Niestroj,Maciej Winiarski, Anna Bryska,Lydia Kopplin,Ana M. Izcue,Janardhan Bhattarai, Yingqi Wang, Alicja Puacian,Minghong Ma,Pavel Stopka,Oliver Pabst,
CHEMICAL SENSES (2023)
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biorxiv(2023)
CHEMICAL SENSES (2023)
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